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Peptide record

TPDB07385

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07385
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LLKLLLKLLLKLL
Physicochemical Analysis
C78H148N16O14
ARNDCEQGHIMFPSTWYV
L
1534.13
10.84
3
0
10
+3
-2.63
2.023
300.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
10
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 10 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C78H148N16O14
1534.13
10.84
+3
-2.63
2.023
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
2 µM
Hemolytic Cytotoxic
5% Hemolysis | 2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of mirror-like peptides with alanine regulation. | Amino Acids | 2016
Evidence 2 Activity

Activity

50% Killing
Toxicity
64 µM
Cytotoxic
50% Killing | 64 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Rational design of mirror-like peptides with alanine regulation. | Amino Acids | 2016
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26385363] MHC5=2 µM against human red blood cells | Cytotoxicity: [Ref.26385363] The cell viability of HEK293 cells induced by KL10A0 is 93.9%, 93.3%, 81.9%, 77.2%, 75.6%, 67.8%, 51.9% and 19.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 µM. The cell viability of HEK293 cells induced by control Melitti

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2016 Feb 48(2):403-17. doi: 10.1007/s00726-015-2094-y.