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Peptide record

TPDB07379

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07379
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
LWKRWVGVWRKWL
Physicochemical Analysis
C92H133N25O14
ANDCEQHIMFPSTY
W
1813.23
12.42
4
0
8
+4
-4.77
-0.369
104.62
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
22000
1213.31
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
2
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 2
Chemical Descriptors
13
C92H133N25O14
1813.23
12.42
+4
-4.77
-0.369
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
19.5 µM
Cytotoxic
IC50 | 19.5 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers. | Cell Mol Bioeng | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
19 µM
Cytotoxic
IC50 | 19 | µM | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers. | Cell Mol Bioeng | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
19.5 µM
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HUVEC: IC50=19.5 µM NL20: IC50=19.0 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell Mol Bioeng. 2020 Jun 24 13(5):447-461.