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Peptide record

TPDB07370

Antibacterial Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07370
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ILKKIWEGIKSLF
Physicochemical Analysis
C78H127N17O17
ARNDCQHMPTYV
IK
1574.97
10.32
3
1
7
+2
0.10
0.508
150.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
349.21
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
3
I
2
L
3
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C78H127N17O17
1574.97
10.32
+2
0.10
0.508
Evidence Records 6 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
IsCT-based Analogs Intending Better Biological Activity | J Pept Sci
Evidence 2 Activity

Activity

85% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
85% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
IsCT-based Analogs Intending Better Biological Activity | J Pept Sci
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
84 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 84 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
211 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 211 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 5 Activity

Activity

LC
Toxicity
256 µg/mL
Cytotoxic
LC | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 6 Activity

Activity

LC50
Toxicity
69.4 µg/mL
Cytotoxic
LC50 | 69.4 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024