TPDB

3D PDB MODEL

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TPDB ID TPDB07367

Peptide_Name

Neurotensin

Activity

Antibacterial Antifungal Neuropeptide

Activity_category_statistics

Anti-infective peptides Neuroactive peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Neuropeptide) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

QLYENKPRRPYIL

FASTA

>TPDB07367|Antibacterial;Antifungal;Neuropeptide|length=13
QLYENKPRRPYIL

Formula C78H124N22O20

Absent Amino Acids ADCGHMFSTWV

Common Amino Acids RLPY

Mass 1689.98

PI 10.08

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 5

Net Charge +2

Boman Index 3.22

Hydrophobicity -1.315

Aliphatic Index 90.00

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 176.33

Polar Residues 4

number

0

A

2

R

1

N

0

D

0

C

1

E

1

Q

0

G

0

H

1

I

2

L

1

K

0

M

0

F

2

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 1 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 2 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

13

Formula

C78H124N22O20

Mass

1689.98

PI

10.08

Net Charge

+2

Boman Index

3.22

Hydrophobicity

-1.315

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Ciona intestinalis

Family Neurotensin

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neurotensin receptor type 1 Neurotensin receptor type 2 Sortilin

Receptor Organisms Rattus norvegicus Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Neurotensin

Receptor Lengths 424 416 825

Receptor Ligands NP07534 NP07523 NP07534 NP07523 NP07520 NP07521 NP07534 NP07522 NP07523 NP07524

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Neurotensin

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Canis lupus familiaris

Family Neurotensin

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neurotensin receptor type 1 Neurotensin receptor type 2

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Neurotensin

Receptor Lengths 418 410

Receptor Ligands NP07531 NP07531

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neurotensin receptor type 1 Neurotensin receptor type 2

Receptor Organisms Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Neurotensin

Receptor Lengths 424 416

Receptor Ligands NP07515 NP07532 NP07515 NP07532

Family

Neurotensin

Receptor_Lengths

424 416 825 418 410

Receptor_Ligands

NP07534 NP07523 NP07520 NP07521 NP07522 NP07524 NP07531 NP07515 NP07532