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Peptide record

TPDB07351

Antibacterial Antifungal Antiviral Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07351
Antibacterial Antifungal Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb DRAVP 2.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FVPWFSKFLKRIL
Physicochemical Analysis
C87H129N19O15
ANDCEQGHMTY
F
1681.10
11.64
3
0
8
+3
-3.23
0.700
112.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
327.17
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
2
K
0
M
3
F
1
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 2 M: 0 F: 3 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
13
C87H129N19O15
1681.10
11.64
+3
-3.23
0.700
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28863356]49.30 ± 2.88% cytotoxic effect at 12.5 µM, 66.86 ± 2.81% cytotoxic effect at 25 µM, 96.79 ± 1.24% cytotoxic effect at 50 µM on HaCaT cells. | Cytotoxicity: [Ref.28863356] The cytotoxic effect is 49.30±2.88%, 66.86±2.81% and 96.79±1.24% at peptide concentrations of 12.5, 25 and 50 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2017 Oct 20 139:750-761.
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
4 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28863356]7±4% hemolysis at 50 µM, 5±3% hemolysis at 25 µM, 5±2% hemolysis at 12.5 µM, 1±2% hemolysis at 6.25 µM, 0±1% hemolysis at 3.125 µM against human red blood cells. ##28.22 ± 3.52% cytotoxic effect at 25 µM, 87.9 ± 1.07% cytotoxic effect at 50 µM on HaCaT cells. | Cytotoxicity: [Ref.28863356] The cytotoxic effect is 0%, 28.22±3.52% and 87.9±1.07% at 12.5, 25 and 50 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2017 Oct 20 139:750-761.