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Peptide record

TPDB07347

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07347
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept CAFPdb i2APP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ILPFKFPFFPFRR
Physicochemical Analysis
C90H126N20O14
ANDCEQGHMSTWYV
F
1712.12
12.41
3
0
7
+3
-2.56
0.354
60.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
5
F
3
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 5 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C90H126N20O14
1712.12
12.41
+3
-2.56
0.354
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

B. subtilis IFO 3513

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ B. subtilis IFO 3513 (MIC 12.5 ug/ml), S. aureus IFO 12732 (MIC 6.25 ug/ml), and Gram- E. coli IFO 12734 (MIC 100 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Staphylococcus aureus IFO 12732

Source & Reference

dbAMP

Other

Active against Gram+ B. subtilis IFO 3513 (MIC 12.5 ug/ml), S. aureus IFO 12732 (MIC 6.25 ug/ml), and Gram- E. coli IFO 12734 (MIC 100 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Escherichia coli IFO 12734

Source & Reference

dbAMP

Other

m+ B. subtilis IFO 3513 (MIC 12.5 ug/ml), S. aureus IFO 12732 (MIC 6.25 ug/ml), and Gram- E. coli IFO 12734 (MIC 100 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

B. subtilis IFO 3513

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ B. subtilis IFO 3513 (MIC 12.5 ug/ml), S. aureus IFO 12732 (MIC 6.25 ug/ml), and Gram- E. coli IFO 12734 (MIC 100 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

Staphylococcus aureus IFO 12732

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ B. subtilis IFO 3513 (MIC 12.5 ug/ml), S. aureus IFO 12732 (MIC 6.25 ug/ml), and Gram- E. coli IFO 12734 (MIC 100 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

Escherichia coli IFO 12734

Source & Reference

dbAMP CAFPdb Antifungipept

Other

m+ B. subtilis IFO 3513 (MIC 12.5 ug/ml), S. aureus IFO 12732 (MIC 6.25 ug/ml), and Gram- E. coli IFO 12734 (MIC 100 ug/ml).
Evidence 7 Activity

Activity

MIC
Antiparasitic
12.5 µg/mL

Target

B. subtilis IFO 3513

Source & Reference

NA

Other

Active against Gram+ B. subtilis IFO 3513 (MIC 12.5 ug/ml), S. aureus IFO 12732 (MIC 6.25 ug/ml), and Gram- E. coli IFO 12734 (MIC 100 ug/ml).
Evidence 8 Activity

Activity

MIC
Antiparasitic
6.25 µg/mL

Target

Staphylococcus aureus IFO 12732

Source & Reference

NA

Other

Active against Gram+ B. subtilis IFO 3513 (MIC 12.5 ug/ml), S. aureus IFO 12732 (MIC 6.25 ug/ml), and Gram- E. coli IFO 12734 (MIC 100 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

Escherichia coli IFO 12734

Source & Reference

NA

Other

m+ B. subtilis IFO 3513 (MIC 12.5 ug/ml), S. aureus IFO 12732 (MIC 6.25 ug/ml), and Gram- E. coli IFO 12734 (MIC 100 ug/ml).
Evidence 10 Activity

Activity

6% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
6% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of indolicidin, a Trp-rich antibacterial peptide. | J Pept Sci | 2010
Evidence 11 Activity

Activity

100% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
100% Hemolysis | 125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-function relationships in the tryptophan-rich, antimicrobial peptide indolicidin. | J Pept Sci | 2001
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Indolicidin analogs with broad-spectrum antimicrobial activity and low hemolytic activity | Peptides | 2020
Evidence 13 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis