Back to search

Peptide record

TPDB07346

Antibacterial Antifungal Antiviral Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07346
Antibacterial Antifungal Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb DRAVP 2.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FVPWFSKFLWRIL
Physicochemical Analysis
C92H127N19O15
ANDCEQGHMTY
F
1739.14
11.49
2
0
9
+2
-6.07
0.931
112.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
632.50
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
1
K
0
M
3
F
1
P
1
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 1 M: 0 F: 3 P: 1 S: 1 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
13
C92H127N19O15
1739.14
11.49
+2
-6.07
0.931
Evidence Records 2 records
Evidence 1 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28863356]37±1% hemolysis at 50µM, 20±3% hemolysis at 25µM, 7±1% hemolysis at 12.5µM, 4±2% hemolysis at 6.25µM, 2±1% hemolysis at 3.125µM against human red blood cells.##32.1 ± 2.21% cytotoxic effect at 25µM, 89.3 ± 0.8% cytotoxic effect at 50 µM on HaCaT cells. | Cytotoxicity: [Ref.28863356] The cytotoxic effect is 0%, 32.1±2.21% and 89.3±0.8% at 12.5, 25 and 50 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2017 Oct 20 139:750-761.
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28863356]19.21 ± 1.44% cytotoxic effect at 12.5µM, 35.34 ± 5.99% cytotoxic effect at 25µM, 96.77 ± 0.81% cytotoxic effect at 50 µM on HaCaT cells. | Cytotoxicity: [Ref.28863356] The cytotoxic effect is 19.21±1.44%, 35.34±5.99% and 96.77±0.81% at 12.5, 25 and 50 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2017 Oct 20 139:750-761.