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Peptide record

TPDB07345

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07345
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRPWRWPRWPWRR
Physicochemical Analysis
C95H135N35O14
ANDCEQGHILKMFSTYV
R
1991.34
13.10
6
0
4
+6
-1.19
-2.723
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1104.78
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
13
C95H135N35O14
1991.34
13.10
+6
-1.19
-2.723
Evidence Records 3 records
Evidence 1 Activity

Activity

2.39% hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
2.39% hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26046345] The hemolytic activities of IN3 is 2.39% at 250µg/ml against human RBCs. | Cytotoxicity: [Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 62.5 µg/ml. The cell viability of NL-20 is 93% and 26% at peptide concentrations of 125 and 250 µg/ml.## The cell viability of WRL-68 cell line is not affected (<10%) bel

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2015 Jun 5 10(6):e0128532.