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Peptide record

TPDB07336

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07336
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLSTLWNAAKSIF
Physicochemical Analysis
C73H108N16O18
RDCEQGHMPYV
ALFS
1497.76
10.10
1
0
8
+1
-4.07
0.823
105.38
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
367.22
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
1
K
0
M
2
F
0
P
2
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 1 M: 0 F: 2 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C73H108N16O18
1497.76
10.10
+1
-4.07
0.823
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (M
Evidence 2 Activity

Activity

MIC
Antibacterial
20 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (M
Evidence 4 Activity

Activity

MIC
Antibacterial
5 µM

Target

S. typhi ATCC 6399

Source & Reference

dbAMP DRAMP

Other

TCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP DRAMP

Other

lis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
20 µM

Target

Streptococcus agalactiae

Source & Reference

dbAMP DRAMP

Other

5922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
10 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (M
Evidence 8 Activity

Activity

MIC
Antifungal
20 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (
Evidence 9 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (M
Evidence 10 Activity

Activity

MIC
Antifungal
5 µM

Target

S. typhi ATCC 6399

Source & Reference

dbAMP DRAMP Antifungipept

Other

TCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM).
Evidence 11 Activity

Activity

MIC
Antifungal
10 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP DRAMP Antifungipept

Other

lis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
20 µM

Target

Streptococcus agalactiae

Source & Reference

dbAMP DRAMP Antifungipept

Other

5922 (MIC 25 uM), S. typhi ATCC 6399 (MIC 5 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM).
Evidence 13 Activity

Activity

% Hemolysis
Hemolysis
25 84 %
[Ref.22342498]25% hemolytic activity at 25 µM, 84% hemolytic activity at 50 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Peptides. 2012 Apr 34(2):290-295.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

84% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
84% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae. | Peptides | 2012
Evidence 15 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.22342498]25% hemolytic activity at 25 µM, 84% hemolytic activity at 50 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Apr 34(2):290-295.
Evidence 16 Hemolysis

Activity

25 84 %
% Hemolysis
[Ref.22342498]25% hemolytic activity at 25 µM, 84% hemolytic activity at 50 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Peptides. 2012 Apr 34(2):290-295.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.