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Peptide record

TPDB07335

Pantinin-3 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard

13 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07335

Peptide_Name

Pantinin-3

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLSTIWNGIKSLL

FASTA

>TPDB07335|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=13
FLSTIWNGIKSLL

Formula C72H114N16O18

Absent Amino Acids ARDCEQHMPYV

Common Amino Acids L

Mass 1491.79

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +1

Boman Index -3.46

Hydrophobicity 0.938

Aliphatic Index 150.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 368.68

Polar Residues 4

number

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 1 M: 0 F: 1 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 0

Length

Formula

C72H114N16O18

Mass

1491.79

10.10

Net Charge

Boman Index

-3.46

Hydrophobicity

0.938

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-16 µM

Target

Target Organism MRSA 16472

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

tive S. aureus AB 94004, B. magaterium AB 90008, M. luteus AB2010179, VRE S13 (anti-VRE), MRSA 16472 (MIC 4-16 uM), Gram-negative E. coli DH5alpha, K. oxytoca AB 2010143, S. enterica AB 2010185 (MIC 36-87

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 36-87 µM

Target

Target Organism S. enterica AB 2010185

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ti-VRE), MRSA 16472 (MIC 4-16 uM), Gram-negative E. coli DH5alpha, K. oxytoca AB 2010143, S. enterica AB 2010185 (MIC 36-87 uM), and fungus C. tropicalis AY 91009 (MIC 17 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 17 µM

Target

Target Organism C. tropicalis AY 91009

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

. coli DH5alpha, K. oxytoca AB 2010143, S. enterica AB 2010185 (MIC 36-87 uM), and fungus C. tropicalis AY 91009 (MIC 17 uM).

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 13.5 ± 2.0 µM

Detail Source Activity Anticancer

Activity Measurement 13.5

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-231

Tissue Affected Breast

Assay & Model

Assay MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2018

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 17.3 ± 1.0 µM

Detail Source Activity Anticancer

Activity Measurement 17.3

Target

Cancer Type Prostate Cancer

Cell Line DU-145

Tissue Affected Prostate

Assay & Model

Assay MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2018

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4-16 µM

Target

Target Organism MRSA 16472

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 36-87 µM

Target

Target Organism S. enterica AB 2010185

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

ti-VRE), MRSA 16472 (MIC 4-16 uM), Gram-negative E. coli DH5alpha, K. oxytoca AB 2010143, S. enterica AB 2010185 (MIC 36-87 uM), and fungus C. tropicalis AY 91009 (MIC 17 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 17 µM

Target

Target Organism C. tropicalis AY 91009

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

. coli DH5alpha, K. oxytoca AB 2010143, S. enterica AB 2010185 (MIC 36-87 uM), and fungus C. tropicalis AY 91009 (MIC 17 uM).

Evidence 9 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 70 100 100 %

Hemolysis Raw

[Ref.23624072]70% hemolytic activity at 16 µM, 100% hemolytic activity at 32 µM, 100% hemolytic activity at 64 µM against human red blood cells

Target

RBC Target human red blood cells

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

Peptides 45:28-34(2013)##Peptides 51:35-45(2014

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 10 Activity

Activity

Activity Endpoint 70% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 16 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

70% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Three new antimicrobial peptides from the scorpion Pandinus imperator. | Peptides | 2013

Evidence 11 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Three new antimicrobial peptides from the scorpion Pandinus imperator. | Peptides | 2013

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 26.0±1.0 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 26.0±1.0 | µM | target cell: Human gingival fibroblasts

Target

Target Cell Human gingival fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Biophysical characterization and antitumor activity of synthetic Pantinin peptides from scorpion's venom | Biochim Biophys Acta | 2018

Evidence 13 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.23624072]70% hemolytic activity at 16 µM, 100% hemolytic activity at 32 µM, 100% hemolytic activity at 64 µM against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides 45:28-34(2013)##Peptides 51:35-45(2014

Evidence 14 Hemolysis

Activity

Activity Measurement 70 100 100 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.23624072]70% hemolytic activity at 16 µM, 100% hemolytic activity at 32 µM, 100% hemolytic activity at 64 µM against human red blood cells

Detail Source Activity Hemolysis

Target

RBC Target human red blood cells

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

Peptides 45:28-34(2013)##Peptides 51:35-45(2014

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.