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Peptide record

TPDB07329

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07329
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 dbACP iACP-DRLF Antifungipept CAFPdb dbAMP 3.0 i2APP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGALWNVAKSVF
Physicochemical Analysis
C72H106N16O16
RDCEQHIMPTY
ALFV
1451.73
10.10
1
0
9
+1
-3.88
1.208
120.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
378.86
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
1
K
0
M
2
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
13
C72H106N16O16
1451.73
10.10
+1
-3.88
1.208
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (M
Evidence 2 Activity

Activity

MIC
Antibacterial
20 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027
Evidence 3 Activity

Activity

MIC
Antibacterial
20 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (
Evidence 4 Activity

Activity

MIC
Antibacterial
10 µM

Target

S. typhi ATCC 6399

Source & Reference

dbAMP DRAMP

Other

TCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM). Also have anticancer
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP DRAMP

Other

is ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM). Also have anticancer activity against MCF-7 mammary cance
Evidence 6 Activity

Activity

MIC
Antibacterial
20 µM

Target

Streptococcus agalactiae

Source & Reference

dbAMP DRAMP

Other

922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM). Also have anticancer activity against MCF-7 mammary cancer cells ( Pedron et al. 2017 ).
Evidence 7 Activity

Activity

MIC
Antifungal
10 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (M
Evidence 8 Activity

Activity

MIC
Antifungal
20 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027
Evidence 9 Activity

Activity

MIC
Antifungal
20 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (
Evidence 10 Activity

Activity

MIC
Antifungal
10 µM

Target

S. typhi ATCC 6399

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

TCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM). Also have anticancer
Evidence 11 Activity

Activity

MIC
Antifungal
10 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

is ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM). Also have anticancer activity against MCF-7 mammary cance
Evidence 12 Activity

Activity

MIC
Antifungal
20 µM

Target

Streptococcus agalactiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM). Also have anticancer activity against MCF-7 mammary cancer cells ( Pedron et al. 2017 ).
Evidence 13 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (M
Evidence 14 Activity

Activity

MIC
Antiparasitic
20 µM

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027
Evidence 15 Activity

Activity

MIC
Antiparasitic
20 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus ATCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (
Evidence 16 Activity

Activity

MIC
Antiparasitic
10 µM

Target

S. typhi ATCC 6399

Source & Reference

dbAMP 3.0 DRAMP

Other

TCC 25923 (MIC 10 uM), B. subtilis ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM). Also have anticancer
Evidence 17 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP 3.0 DRAMP

Other

is ATCC 6633 (MIC 20 uM), E. coli ATCC 25922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM). Also have anticancer activity against MCF-7 mammary cance
Evidence 18 Activity

Activity

MIC
Antiparasitic
20 µM

Target

Streptococcus agalactiae

Source & Reference

dbAMP 3.0 DRAMP

Other

922 (MIC 20 uM), S. typhi ATCC 6399 (MIC 10 uM), P. aeruginosa ATCC 9027 (MIC 10 uM), and S. agalactiae (MIC 20 uM). Also have anticancer activity against MCF-7 mammary cancer cells ( Pedron et al. 2017 ).
Evidence 19 Activity

Activity

12% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
12% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae. | Peptides | 2012
Evidence 20 Activity

Activity

0% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel designed VmCT1 analogs with increased antimicrobial activity. | Eur J Med Chem | 2017
Evidence 21 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic
Hemolytic_activity: [Ref.27912176] 10% hemolysis at 1.99µmol/L against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2017 Jan 27 126:456-463.
Evidence 22 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.