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Peptide record

TPDB07327

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

13 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07327

Activity

Antibacterial Anticancer Antidiabetic Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

TSRCIFYRRKKCS

FASTA

>TPDB07327|Antibacterial;Anticancer;Antidiabetic;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=13
TSRCIFYRRKKCS

Formula C70H118N24O18S2

Absent Amino Acids ANDEQGHLMPWV

Common Amino Acids R

Mass 1647.98

PI 10.70

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +5

Boman Index 1.95

Hydrophobicity -0.969

Aliphatic Index 30.00

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1615

Absorbance 280nm 98.00

Polar Residues 6

number

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 1 V: 0

Length

Formula

C70H118N24O18S2

Mass

1647.98

10.70

Net Charge

Boman Index

1.95

Hydrophobicity

-0.969

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram- bacteria E. coli (MIC 30 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >1

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >120 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

i (MIC 30 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >120 ug/ml), and yeast C. albicans (MIC 30 ug/ml). Updated 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >120 ug/ml), and yeast C. albicans (MIC 30 ug/ml). Updated 7/2021

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram- bacteria E. coli (MIC 30 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >1

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >120 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

i (MIC 30 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >120 ug/ml), and yeast C. albicans (MIC 30 ug/ml). Updated 7/2021

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >120 ug/ml), and yeast C. albicans (MIC 30 ug/ml). Updated 7/2021

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against Gram- bacteria E. coli (MIC 30 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >1

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >120 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

i (MIC 30 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >120 ug/ml), and yeast C. albicans (MIC 30 ug/ml). Updated 7/2021

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >120 ug/ml), and yeast C. albicans (MIC 30 ug/ml). Updated 7/2021

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against Gram- bacteria E. coli (MIC 30 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >1

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement >120 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

i (MIC 30 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >120 ug/ml), and yeast C. albicans (MIC 30 ug/ml). Updated 7/2021

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 30 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

called P. aeruginosa) (MIC 30 ug/ml), Gram+ bacteria S.aureus (MIC >120 ug/ml), and yeast C. albicans (MIC 30 ug/ml). Updated 7/2021

Evidence 13 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 2.1 %

Hemolysis Raw

[Ref:22029824] It has 15.2±2.1% hemolytic activity at 50µg/ml against human red blood cells

Target

RBC Target human red blood cells

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

J Proteome Res. 2012 Jan 1 11(1):306-319.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 15% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

15% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. | J Proteome Res | 2012

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:22029824] It has 15.2±2.1% hemolytic activity at 50µg/ml against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Proteome Res. 2012 Jan 1 11(1):306-319.

Evidence 16 Hemolysis

Activity

Activity Measurement 2.1 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref:22029824] It has 15.2±2.1% hemolytic activity at 50µg/ml against human red blood cells

Detail Source Activity Hemolysis

Target

RBC Target human red blood cells

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

J Proteome Res. 2012 Jan 1 11(1):306-319.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.