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Peptide record

TPDB07326

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07326
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept dbAMP 3.0 APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IWSAIWSGIKGLL
Physicochemical Analysis
C71H110N16O16
RNDCEQHMFPTYV
I
1443.75
10.10
1
0
8
+1
-4.65
1.138
157.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
11000
761.90
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
2
L
1
K
0
M
0
F
0
P
2
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 2 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
13
C71H110N16O16
1443.75
10.10
+1
-4.65
1.138
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 1 uM), P. aeruginosa (MIC 15 uM), and E. coli (MIC 2 uM). Most potent in this series of peptide
Evidence 2 Activity

Activity

MIC
Antibacterial
15 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 1 uM), P. aeruginosa (MIC 15 uM), and E. coli (MIC 2 uM). Most potent in this series of peptides.
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 1 uM), P. aeruginosa (MIC 15 uM), and E. coli (MIC 2 uM). Most potent in this series of peptides.
Evidence 4 Activity

Activity

MIC
Antifungal
1 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 1 uM), P. aeruginosa (MIC 15 uM), and E. coli (MIC 2 uM). Most potent in this series of peptide
Evidence 5 Activity

Activity

MIC
Antifungal
15 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against S. aureus (MIC 1 uM), P. aeruginosa (MIC 15 uM), and E. coli (MIC 2 uM). Most potent in this series of peptides.
Evidence 6 Activity

Activity

MIC
Antifungal
2 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against S. aureus (MIC 1 uM), P. aeruginosa (MIC 15 uM), and E. coli (MIC 2 uM). Most potent in this series of peptides.
Evidence 7 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against S. aureus (MIC 1 uM), P. aeruginosa (MIC 15 uM), and E. coli (MIC 2 uM). Most potent in this series of peptide
Evidence 8 Activity

Activity

MIC
Antiparasitic
15 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus (MIC 1 uM), P. aeruginosa (MIC 15 uM), and E. coli (MIC 2 uM). Most potent in this series of peptides.
Evidence 9 Activity

Activity

MIC
Antiparasitic
2 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus (MIC 1 uM), P. aeruginosa (MIC 15 uM), and E. coli (MIC 2 uM). Most potent in this series of peptides.
Evidence 10 Activity

Activity

% Hemolysis
Hemolysis
27 65 95 90 %
[Ref.23182832]27% hemolytic activity at 12.5 µM, 65% hemolytic activity at 25 µM, 95% hemolytic activity at 50 µM, 90% hemolytic activity at 100 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Toxicon. 2013 Mar 1 63:44-54.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

0% Hemolysis
Toxicity
2 µM
Hemolytic Cytotoxic
0% Hemolysis | 2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 12 Activity

Activity

37% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
37% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 13 Activity

Activity

93% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
93% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 14 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23182832]27% hemolytic activity at 12.5 µM, 65% hemolytic activity at 25 µM, 95% hemolytic activity at 50 µM, 90% hemolytic activity at 100 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2013 Mar 1 63:44-54.
Evidence 15 Hemolysis

Activity

27 65 95 90 %
% Hemolysis
[Ref.23182832]27% hemolytic activity at 12.5 µM, 65% hemolytic activity at 25 µM, 95% hemolytic activity at 50 µM, 90% hemolytic activity at 100 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete PD_Hemolysis
Toxicon. 2013 Mar 1 63:44-54.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.