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Peptide record

TPDB07325

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07325
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ILGKIWKGIKSLF
Physicochemical Analysis
C75H123N17O15
ARNDCEQHMPTYV
IK
1502.91
10.84
3
0
7
+3
-1.91
0.746
150.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
365.96
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
2
L
3
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 2 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C75H123N17O15
1502.91
10.84
+3
-1.91
0.746
Evidence Records 7 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
23.29 µM
Hemolytic Cytotoxic
0% Hemolysis | 23.29 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anticancer Activities of Antimicrobial BmKn2 Peptides Against Oral and Colon Cancer Cells | Int J Pept Res Ther | 2014
Evidence 2 Activity

Activity

8% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
8% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs. | Biochem Biophys Res Commun | 2004
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs. | Biochem Biophys Res Commun | 2004
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides. | Antibiotics (Basel) | 2017
Evidence 5 Activity

Activity

65% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
65% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides. | Antibiotics (Basel) | 2017
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
92.17 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 92.17 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An unprecedented alteration in mode of action of IsCT resulting its translocation into bacterial cytoplasm and inhibition of macromolecular syntheses. | Sci Rep | 2015
Evidence 7 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis