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Peptide record

TPDB07322

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07322
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IFGAIWNGIKSLF
Physicochemical Analysis
C73H108N16O16
RDCEQHMPTYV
I
1465.76
10.10
1
0
8
+1
-4.21
1.138
127.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
375.23
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
1
L
1
K
0
M
2
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 1 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C73H108N16O16
1465.76
10.10
+1
-4.21
1.138
Evidence Records 26 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.7 µM

Target

Staphylococcus aureus ATCC 25293

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Inhibited Gram+ S. aureus ATCC 25293 (MIC 0.7 uM), S. aureus ATCC 6538 (MIC 3.4 uM), S. saprophyticus clincal strain (MIC 0.7 uM), B. thuri
Evidence 2 Activity

Activity

MIC
Antibacterial
3.4 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP

Other

Inhibited Gram+ S. aureus ATCC 25293 (MIC 0.7 uM), S. aureus ATCC 6538 (MIC 3.4 uM), S. saprophyticus clincal strain (MIC 0.7 uM), B. thuringensis (MIC 17.1 uM), B. subtilis
Evidence 3 Activity

Activity

MIC
Antibacterial
0.7 µM

Target

S. saprophyticus clincal strain

Source & Reference

dbAMP DRAMP

Other

Inhibited Gram+ S. aureus ATCC 25293 (MIC 0.7 uM), S. aureus ATCC 6538 (MIC 3.4 uM), S. saprophyticus clincal strain (MIC 0.7 uM), B. thuringensis (MIC 17.1 uM), B. subtilis CCT 2471 (6.8 uM), Gram- P.aeroginosa ATCC 15
Evidence 4 Activity

Activity

MIC
Antibacterial
17.1 µM

Target

B. thuringensis

Source & Reference

dbAMP DRAMP

Other

0.7 uM), S. aureus ATCC 6538 (MIC 3.4 uM), S. saprophyticus clincal strain (MIC 0.7 uM), B. thuringensis (MIC 17.1 uM), B. subtilis CCT 2471 (6.8 uM), Gram- P.aeroginosa ATCC 15442 (MIC>150 uM), P. aeroginosa
Evidence 5 Activity

Activity

MIC
Antibacterial
>150 µM

Target

P.aeroginosa ATCC 15442

Source & Reference

dbAMP DRAMP

Other

strain (MIC 0.7 uM), B. thuringensis (MIC 17.1 uM), B. subtilis CCT 2471 (6.8 uM), Gram- P.aeroginosa ATCC 15442 (MIC>150 uM), P. aeroginosa ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 2592
Evidence 6 Activity

Activity

MIC
Antibacterial
68.3 µM

Target

P. aeroginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

(MIC 17.1 uM), B. subtilis CCT 2471 (6.8 uM), Gram- P.aeroginosa ATCC 15442 (MIC>150 uM), P. aeroginosa ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM
Evidence 7 Activity

Activity

MIC
Antibacterial
3.4 µM

Target

Escherichia coli CCT 1371

Source & Reference

dbAMP DRAMP

Other

uM), Gram- P.aeroginosa ATCC 15442 (MIC>150 uM), P. aeroginosa ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM), and C. albicans (MIC 12.5 uM
Evidence 8 Activity

Activity

MIC
Antibacterial
6.8 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

5442 (MIC>150 uM), P. aeroginosa ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM), and C. albicans (MIC 12.5 uM). Causing vesicle release.
Evidence 9 Activity

Activity

MIC
Antibacterial
>150 µM

Target

P.mirabilis

Source & Reference

dbAMP DRAMP

Other

ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM), and C. albicans (MIC 12.5 uM). Causing vesicle release.
Evidence 10 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

li CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM), and C. albicans (MIC 12.5 uM). Causing vesicle release.
Evidence 11 Activity

Activity

MIC
Antifungal
0.7 µM

Target

Staphylococcus aureus ATCC 25293

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Inhibited Gram+ S. aureus ATCC 25293 (MIC 0.7 uM), S. aureus ATCC 6538 (MIC 3.4 uM), S. saprophyticus clincal strain (MIC 0.7 uM), B. thuri
Evidence 12 Activity

Activity

MIC
Antifungal
3.4 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Inhibited Gram+ S. aureus ATCC 25293 (MIC 0.7 uM), S. aureus ATCC 6538 (MIC 3.4 uM), S. saprophyticus clincal strain (MIC 0.7 uM), B. thuringensis (MIC 17.1 uM), B. subtilis
Evidence 13 Activity

Activity

MIC
Antifungal
0.7 µM

Target

S. saprophyticus clincal strain

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Inhibited Gram+ S. aureus ATCC 25293 (MIC 0.7 uM), S. aureus ATCC 6538 (MIC 3.4 uM), S. saprophyticus clincal strain (MIC 0.7 uM), B. thuringensis (MIC 17.1 uM), B. subtilis CCT 2471 (6.8 uM), Gram- P.aeroginosa ATCC 15
Evidence 14 Activity

Activity

MIC
Antifungal
17.1 µM

Target

B. thuringensis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0.7 uM), S. aureus ATCC 6538 (MIC 3.4 uM), S. saprophyticus clincal strain (MIC 0.7 uM), B. thuringensis (MIC 17.1 uM), B. subtilis CCT 2471 (6.8 uM), Gram- P.aeroginosa ATCC 15442 (MIC>150 uM), P. aeroginosa
Evidence 15 Activity

Activity

MIC
Antifungal
>150 µM

Target

P.aeroginosa ATCC 15442

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

strain (MIC 0.7 uM), B. thuringensis (MIC 17.1 uM), B. subtilis CCT 2471 (6.8 uM), Gram- P.aeroginosa ATCC 15442 (MIC>150 uM), P. aeroginosa ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 2592
Evidence 16 Activity

Activity

MIC
Antifungal
68.3 µM

Target

P. aeroginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 17.1 uM), B. subtilis CCT 2471 (6.8 uM), Gram- P.aeroginosa ATCC 15442 (MIC>150 uM), P. aeroginosa ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM
Evidence 17 Activity

Activity

MIC
Antifungal
3.4 µM

Target

Escherichia coli CCT 1371

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), Gram- P.aeroginosa ATCC 15442 (MIC>150 uM), P. aeroginosa ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM), and C. albicans (MIC 12.5 uM
Evidence 18 Activity

Activity

MIC
Antifungal
6.8 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5442 (MIC>150 uM), P. aeroginosa ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM), and C. albicans (MIC 12.5 uM). Causing vesicle release.
Evidence 19 Activity

Activity

MIC
Antifungal
>150 µM

Target

P.mirabilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ATCC 27853 (MIC 68.3 uM), E. coli CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM), and C. albicans (MIC 12.5 uM). Causing vesicle release.
Evidence 20 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

li CCT 1371 (MIC 3.4 uM), E. coli ATCC 25922 (MIC 6.8 uM), P.mirabilis (MIC >150 uM), and C. albicans (MIC 12.5 uM). Causing vesicle release.
Evidence 21 Activity

Activity

% Hemolysis
Hemolysis
18 96 %
[Ref.12054688] Showed relatively weak hemolytic activity against sheep red blood cells.##[Ref.28657596] 18% hemolysis at 10 µg/ml, 96% hemolysis at 50 µg/ml against human red blood cells.

Target

sheep red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Biochem Biophys Res Commun. 2002 May 24 293(5):1514-1522.##Antibiotics (Basel). 2017 Jun 28 6(3). pii: E13.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 22 Activity

Activity

0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0% Hemolysis | 25 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Purification, structure-function analysis, and molecular characterization of novel linear peptides from scorpion Opisthacanthus madagascariensis. | Biochem Biophys Res Commun | 2002
Evidence 23 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Purification, structure-function analysis, and molecular characterization of novel linear peptides from scorpion Opisthacanthus madagascariensis. | Biochem Biophys Res Commun | 2002
Evidence 24 Activity

Activity

95% Hemolysis
Toxicity
50-100 µg/mL
Hemolytic Cytotoxic
95% Hemolysis | 50-100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides. | Antibiotics (Basel) | 2017
Evidence 25 Activity

Activity

% Hemolysis
Toxicity
18 %
Hemolytic
Hemolytic_activity: [Ref.12054688] Showed relatively weak hemolytic activity against sheep red blood cells.##[Ref.28657596] 18% hemolysis at 10 µg/ml, 96% hemolysis at 50 µg/ml against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2002 May 24 293(5):1514-1522.##Antibiotics (Basel). 2017 Jun 28 6(3). pii: E13.
Evidence 26 Hemolysis

Activity

18 96 %
% Hemolysis
[Ref.12054688] Showed relatively weak hemolytic activity against sheep red blood cells.##[Ref.28657596] 18% hemolysis at 10 µg/ml, 96% hemolysis at 50 µg/ml against human red blood cells.
Hemolysis

Target

sheep red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Biochem Biophys Res Commun. 2002 May 24 293(5):1514-1522.##Antibiotics (Basel). 2017 Jun 28 6(3). pii: E13.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.