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Peptide record

TPDB07321

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07321
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FMPILSCSRFKRC
Physicochemical Analysis
C70H114N20O16S3
ANDEQGHTWYV
RCFS
1587.98
10.12
3
0
5
+3
-0.52
0.362
60.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
7.87
4
Residue Composition
number
0
A
2
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
1
M
2
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 1 F: 2 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C70H114N20O16S3
1587.98
10.12
+3
-0.52
0.362
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.7 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml)
Evidence 2 Activity

Activity

MIC
Antibacterial
9.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.
Evidence 3 Activity

Activity

MIC
Antibacterial
37.5 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.
Evidence 4 Activity

Activity

MIC
Antibacterial
1.1 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

nst E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.
Evidence 5 Activity

Activity

MIC
Antifungal
4.7 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml)
Evidence 6 Activity

Activity

MIC
Antifungal
9.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.
Evidence 7 Activity

Activity

MIC
Antifungal
37.5 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.
Evidence 8 Activity

Activity

MIC
Antifungal
1.1 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nst E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.
Evidence 9 Activity

Activity

MIC
Antiparasitic
4.7 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml)
Evidence 10 Activity

Activity

MIC
Antiparasitic
9.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.
Evidence 11 Activity

Activity

MIC
Antiparasitic
37.5 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

active against E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.
Evidence 12 Activity

Activity

MIC
Antiparasitic
1.1 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

nst E. coli (MIC 4.7 ug/ml), S. aureus (MIC 9.4 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 1.1 ug/ml). Aslo histamine release.
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 14 Activity

Activity

0% degranulation
Toxicity
50 µg/mL
Cytotoxic
0% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007
Evidence 15 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:17272268] It has no hemolytic activity against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Cell Proteomics. 2007 May 6(5):882-894.