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Peptide record

TPDB07316

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07316
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept dbAMP 3.0 AI4AVP DRAVP 2.0 ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFGSVLKLIPKIL
Physicochemical Analysis
C75H123N15O15
ARNDCEQHMTWY
L
1474.89
10.60
2
0
8
+2
-1.92
1.508
172.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
3
L
2
K
0
M
2
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 2 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C75H123N15O15
1474.89
10.60
+2
-1.92
1.508
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
e. The L and D-forms of the peptide showed identical antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

of the peptide showed identical antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G 2012 JACS ).
Evidence 3 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus aureus USA300 MRSA

Source & Reference

dbAMP DRAMP

Other

antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G 2012 JACS ).
Evidence 4 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
e. The L and D-forms of the peptide showed identical antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G
Evidence 5 Activity

Activity

MIC
Antifungal
6.25 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP Antifungipept

Other

of the peptide showed identical antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G 2012 JACS ).
Evidence 6 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Staphylococcus aureus USA300 MRSA

Source & Reference

dbAMP DRAMP Antifungipept

Other

antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G 2012 JACS ).
Evidence 7 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
e. The L and D-forms of the peptide showed identical antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G
Evidence 8 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

of the peptide showed identical antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G 2012 JACS ).
Evidence 9 Activity

Activity

MIC
Antiparasitic
3.1 µM

Target

Staphylococcus aureus USA300 MRSA

Source & Reference

dbAMP 3.0 DRAMP

Other

antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G 2012 JACS ).
Evidence 10 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
e. The L and D-forms of the peptide showed identical antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G
Evidence 11 Activity

Activity

MIC
Antiviral
6.25 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

of the peptide showed identical antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G 2012 JACS ).
Evidence 12 Activity

Activity

MIC
Antiviral
3.1 µM

Target

Staphylococcus aureus USA300 MRSA

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

antibacterial activity (D=L) against E. coli (MIC 25 uM), B. subtilis (MIC 6.25 uM), and S. aureus USA300 MRSA (MIC 3.1 uM) ( Mishra B and Wang G 2012 JACS ).
Evidence 13 Activity

Activity

13% Hemolysis
Toxicity
87 µM
Hemolytic Cytotoxic
13% Hemolysis | 87 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Synthetic peptides bioinspired in temporin-PTa with antibacterial and antibiofilm activity. | Chem Biol Drug Des | 2022
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
124.8 µM
Hemolytic Cytotoxic
50% Hemolysis | 124.8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ab initio design of potent anti-MRSA peptides based on database filtering technology. | J Am Chem Soc | 2012
Evidence 15 Activity

Activity

10% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 16 Activity

Activity

LC50
Toxicity
32 µg/mL
Cytotoxic
LC50 | 32 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 17 Activity

Activity

10% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022
Evidence 18 Activity

Activity

LC90
Toxicity
64 µg/mL
Cytotoxic
LC90 | 64 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo | J Med Chem | 2022