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Peptide record

TPDB07315

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07315
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IPPFIKKVLTTVF
Physicochemical Analysis
C76H123N15O16
ARNDCEQGHMSWY
IKFPTV
1502.90
10.60
2
0
7
+2
-0.14
1.108
134.62
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
2
K
0
M
2
F
2
P
0
S
2
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 2 M: 0 F: 2 P: 2 S: 0 T: 2 W: 0 Y: 0 V: 2
Chemical Descriptors
13
C76H123N15O16
1502.90
10.60
+2
-0.14
1.108
Evidence Records 30 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 25 uM), S. aureus (50 uM), and C. albicans (25 uM). In addiiton, it is also active against S. ep
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

5 uM), S. aureus (50 uM), and C. albicans (25 uM). In addiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tr
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

C. albicans (25 uM). In addiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM)
Evidence 4 Activity

Activity

MIC
Antibacterial
50 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

ddiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

G. Glabrata

Source & Reference

dbAMP DRAMP

Other

against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018 ).
Evidence 6 Activity

Activity

MIC
Antibacterial
3.1-6.2 µM

Target

C. tropicalis

Source & Reference

dbAMP DRAMP

Other

5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018 ).
Evidence 7 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 25 uM), S. aureus (50 uM), and C. albicans (25 uM). In addiiton, it is also active against S. ep
Evidence 8 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 uM), S. aureus (50 uM), and C. albicans (25 uM). In addiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tr
Evidence 9 Activity

Activity

MIC
Antifungal
50 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C. albicans (25 uM). In addiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM)
Evidence 10 Activity

Activity

MIC
Antifungal
50 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ddiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018
Evidence 11 Activity

Activity

MIC
Antifungal
12.5 µM

Target

G. Glabrata

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018 ).
Evidence 12 Activity

Activity

MIC
Antifungal
3.1-6.2 µM

Target

C. tropicalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018 ).
Evidence 13 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 25 uM), S. aureus (50 uM), and C. albicans (25 uM). In addiiton, it is also active against S. ep
Evidence 14 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

5 uM), S. aureus (50 uM), and C. albicans (25 uM). In addiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tr
Evidence 15 Activity

Activity

MIC
Antiparasitic
50 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

C. albicans (25 uM). In addiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM)
Evidence 16 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

ddiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018
Evidence 17 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

G. Glabrata

Source & Reference

DRAMP

Other

against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018 ).
Evidence 18 Activity

Activity

MIC
Antiparasitic
3.1-6.2 µM

Target

C. tropicalis

Source & Reference

DRAMP

Other

5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018 ).
Evidence 19 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 25 uM), S. aureus (50 uM), and C. albicans (25 uM). In addiiton, it is also active against S. ep
Evidence 20 Activity

Activity

MIC
Antiviral
12.5 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

5 uM), S. aureus (50 uM), and C. albicans (25 uM). In addiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tr
Evidence 21 Activity

Activity

MIC
Antiviral
50 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

C. albicans (25 uM). In addiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM)
Evidence 22 Activity

Activity

MIC
Antiviral
50 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

ddiiton, it is also active against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018
Evidence 23 Activity

Activity

MIC
Antiviral
12.5 µM

Target

G. Glabrata

Source & Reference

DRAMP

Other

against S. epidermidis (MIC 12.5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018 ).
Evidence 24 Activity

Activity

MIC
Antiviral
3.1-6.2 µM

Target

C. tropicalis

Source & Reference

DRAMP

Other

5 uM), B. subtilis (MIC 50 uM), K. pneumoniae (MIC 50 uM), G. Glabrata (MIC 12.5 uM), and C. tropicalis (MIC 3.1-6.2 uM) ( Mishra Wang et al. 2018 ).
Evidence 25 Activity

Activity

LC50
Hemolysis
220 µM
[Ref:19635516]LC50=220 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides. 2009 Oct 30(10):1775-1781.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
220 µM
Hemolytic Cytotoxic
50% Hemolysis | 220 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the skin secretions of the New World frogs Lithobates capito and Lithobates warszewitschii (Ranidae). | Peptides | 2009
Evidence 27 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins. | Peptides | 2018
Evidence 28 Activity

Activity

LC50
Toxicity
100 µM
Cytotoxic
LC50 | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins. | Peptides | 2018
Evidence 29 Activity

Activity

LC50
Toxicity
220 µM
Hemolytic
Hemolytic_activity: [Ref:19635516]LC50=220 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2009 Oct 30(10):1775-1781.
Evidence 30 Hemolysis

Activity

220 µM
LC50
[Ref:19635516]LC50=220 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides. 2009 Oct 30(10):1775-1781.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.