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Peptide record

TPDB07312

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07312
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IIPLPLGYFAKKT
Physicochemical Analysis
C73H117N15O16
RNDCEQHMSWV
ILKP
1460.82
10.20
2
0
7
+2
-0.95
0.600
127.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1490
102.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
2
L
2
K
0
M
1
F
2
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 2 M: 0 F: 1 P: 2 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C73H117N15O16
1460.82
10.20
+2
-0.95
0.600
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Strongly active against S. aureus (MIC 6 uM) and E. coli (MIC 3 uM). Conflict: Inactive against E.coli AS 1.349 (MIC > 100 uM), P.aeru
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Strongly active against S. aureus (MIC 6 uM) and E. coli (MIC 3 uM). Conflict: Inactive against E.coli AS 1.349 (MIC > 100 uM), P.aeruginosa CGMCC 1.860 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
>100 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

1.72 (MIC > 100 uM), B.cereus AS 1.126 (MIC > 100 uM), S.lactis AS 1.1690 (MIC >100 uM), E.faecalis (MIC >100 uM), E.faecium CGMCC 1.2334 (MIC >100 uM) ( Ji et al., 2022 ).
Evidence 4 Activity

Activity

MIC
Antifungal
6 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Strongly active against S. aureus (MIC 6 uM) and E. coli (MIC 3 uM). Conflict: Inactive against E.coli AS 1.349 (MIC > 100 uM), P.aeru
Evidence 5 Activity

Activity

MIC
Antifungal
3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Strongly active against S. aureus (MIC 6 uM) and E. coli (MIC 3 uM). Conflict: Inactive against E.coli AS 1.349 (MIC > 100 uM), P.aeruginosa CGMCC 1.860 (MIC
Evidence 6 Activity

Activity

MIC
Antifungal
>100 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP Antifungipept

Other

1.72 (MIC > 100 uM), B.cereus AS 1.126 (MIC > 100 uM), S.lactis AS 1.1690 (MIC >100 uM), E.faecalis (MIC >100 uM), E.faecium CGMCC 1.2334 (MIC >100 uM) ( Ji et al., 2022 ).
Evidence 7 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Strongly active against S. aureus (MIC 6 uM) and E. coli (MIC 3 uM). Conflict: Inactive against E.coli AS 1.349 (MIC > 100 uM), P.aeru
Evidence 8 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Strongly active against S. aureus (MIC 6 uM) and E. coli (MIC 3 uM). Conflict: Inactive against E.coli AS 1.349 (MIC > 100 uM), P.aeruginosa CGMCC 1.860 (MIC
Evidence 9 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

Enterococcus faecalis

Source & Reference

DRAMP

Other

1.72 (MIC > 100 uM), B.cereus AS 1.126 (MIC > 100 uM), S.lactis AS 1.1690 (MIC >100 uM), E.faecalis (MIC >100 uM), E.faecium CGMCC 1.2334 (MIC >100 uM) ( Ji et al., 2022 ).
Evidence 10 Activity

Activity

MIC
Antiviral
6 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Strongly active against S. aureus (MIC 6 uM) and E. coli (MIC 3 uM). Conflict: Inactive against E.coli AS 1.349 (MIC > 100 uM), P.aeru
Evidence 11 Activity

Activity

MIC
Antiviral
3 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Strongly active against S. aureus (MIC 6 uM) and E. coli (MIC 3 uM). Conflict: Inactive against E.coli AS 1.349 (MIC > 100 uM), P.aeruginosa CGMCC 1.860 (MIC
Evidence 12 Activity

Activity

MIC
Antiviral
>100 µM

Target

Enterococcus faecalis

Source & Reference

DRAMP

Other

1.72 (MIC > 100 uM), B.cereus AS 1.126 (MIC > 100 uM), S.lactis AS 1.1690 (MIC >100 uM), E.faecalis (MIC >100 uM), E.faecium CGMCC 1.2334 (MIC >100 uM) ( Ji et al., 2022 ).
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs. | Bioorg Chem | 2022
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
>300 µM
Hemolytic Cytotoxic
50% Hemolysis | >300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 15 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.