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Peptide record

TPDB07311

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07311
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IFGAIAGLLKNIF
Physicochemical Analysis
C68H109N15O15
RDCEQHMPSTWYV
I
1376.70
10.10
1
0
9
+1
-3.22
1.700
165.38
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
2
L
1
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 2 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C68H109N15O15
1376.70
10.10
+1
-3.22
1.700
Evidence Records 8 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
37.7 59.2 %
[Ref.19088182]37.7% hemolytic activity at 6.25 M, 59.2% hemolytic activity at 12.5 M against rabbit red blood cells

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
FASEB J. 2009 Apr 23(4):1230-1245.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

38% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
38% Hemolysis | 6.25 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. | FASEB J | 2009
Evidence 3 Activity

Activity

59% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
59% Hemolysis | 12.5 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. | FASEB J | 2009
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
100% Hemolysis | 25 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. | FASEB J | 2009
Evidence 5 Activity

Activity

25% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
25% Hemolysis | 25 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. | FASEB J | 2009
Evidence 6 Activity

Activity

100% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
100% Hemolysis | 25 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. | Front Microbiol | 2018
Evidence 7 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.19088182]37.7% hemolytic activity at 6.25 M, 59.2% hemolytic activity at 12.5 M against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
FASEB J. 2009 Apr 23(4):1230-1245.
Evidence 8 Hemolysis

Activity

37.7 59.2 %
% Hemolysis
[Ref.19088182]37.7% hemolytic activity at 6.25 M, 59.2% hemolytic activity at 12.5 M against rabbit red blood cells
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
FASEB J. 2009 Apr 23(4):1230-1245.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.