Back to search

Peptide record

TPDB07308

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07308
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLVTMLLGKLF
Physicochemical Analysis
C75H122N14O15S1
ARNDCEQHISWY
L
1491.94
10.10
1
0
9
+1
-3.63
1.854
172.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
5
L
1
K
1
M
2
F
1
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 5 K: 1 M: 1 F: 2 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C75H122N14O15S1
1491.94
10.10
+1
-3.63
1.854
Evidence Records 28 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus aureus NCTC8325

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 10 uM), E. faecalis ATCC 29212 (MIC 40
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 10 uM), E. faecalis ATCC 29212 (MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.col
Evidence 3 Activity

Activity

MIC
Antibacterial
40 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 10 uM), E. faecalis ATCC 29212 (MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumon
Evidence 4 Activity

Activity

MIC
Antibacterial
>160 µM

Target

E.coli ATCC25922

Source & Reference

dbAMP DRAMP

Other

0 uM), E. faecalis ATCC 29212 (MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNT
Evidence 5 Activity

Activity

MIC
Antibacterial
80 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP

Other

MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC
Evidence 6 Activity

Activity

MIC
Antibacterial
160 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

TCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC>160 uM). Toxicity: moderate hemolytic
Evidence 7 Activity

Activity

MIC
Antibacterial
40 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

dbAMP DRAMP

Other

2 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC>160 uM). Toxicity: moderate hemolytic HC50 30 uM. Updated 5/2020 7/2021
Evidence 8 Activity

Activity

MIC
Antibacterial
>160 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC>160 uM). Toxicity: moderate hemolytic HC50 30 uM. Updated 5/2020 7/2021
Evidence 9 Activity

Activity

MIC
Antifungal
5 µM

Target

Staphylococcus aureus NCTC8325

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 10 uM), E. faecalis ATCC 29212 (MIC 40
Evidence 10 Activity

Activity

MIC
Antifungal
10 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 10 uM), E. faecalis ATCC 29212 (MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.col
Evidence 11 Activity

Activity

MIC
Antifungal
40 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 10 uM), E. faecalis ATCC 29212 (MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumon
Evidence 12 Activity

Activity

MIC
Antifungal
>160 µM

Target

E.coli ATCC25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0 uM), E. faecalis ATCC 29212 (MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNT
Evidence 13 Activity

Activity

MIC
Antifungal
80 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC
Evidence 14 Activity

Activity

MIC
Antifungal
160 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

TCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC>160 uM). Toxicity: moderate hemolytic
Evidence 15 Activity

Activity

MIC
Antifungal
40 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC>160 uM). Toxicity: moderate hemolytic HC50 30 uM. Updated 5/2020 7/2021
Evidence 16 Activity

Activity

MIC
Antifungal
>160 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC>160 uM). Toxicity: moderate hemolytic HC50 30 uM. Updated 5/2020 7/2021
Evidence 17 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Staphylococcus aureus NCTC8325

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 10 uM), E. faecalis ATCC 29212 (MIC 40
Evidence 18 Activity

Activity

MIC
Antiparasitic
10 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

DRAMP

Other

Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 10 uM), E. faecalis ATCC 29212 (MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.col
Evidence 19 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 10 uM), E. faecalis ATCC 29212 (MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumon
Evidence 20 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

E.coli ATCC25922

Source & Reference

DRAMP

Other

0 uM), E. faecalis ATCC 29212 (MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNT
Evidence 21 Activity

Activity

MIC
Antiparasitic
80 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

DRAMP

Other

MIC 40 uM), Streptococcus group B HNTCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC
Evidence 22 Activity

Activity

MIC
Antiparasitic
160 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

TCC 80130 (MIC 40 uM), E.coli ATCC25922 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC>160 uM). Toxicity: moderate hemolytic
Evidence 23 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

DRAMP

Other

2 (MIC>160 uM), K. pneumoniae KK3 9904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC>160 uM). Toxicity: moderate hemolytic HC50 30 uM. Updated 5/2020 7/2021
Evidence 24 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

C.albicans

Source & Reference

DRAMP

Other

904 (MIC 80 uM), P.aeruginosa ATCC 27853 (MIC 160 uM), E. cloacae HNTCC 53001(MIC 40 uM), C.albicans (MIC>160 uM). Toxicity: moderate hemolytic HC50 30 uM. Updated 5/2020 7/2021
Evidence 25 Activity

Activity

Hemolysis
[Ref:15996769]LD50=30 µM against washed human erythrocytes

Target

washed human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Regul Pept. 2005 Nov 131(1-3):38-45.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
50% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). | Regul Pept | 2005
Evidence 27 Activity

Activity

LD50
Toxicity
30 µM
Hemolytic
Hemolytic_activity: [Ref:15996769]LD50=30 µM against washed human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Regul Pept. 2005 Nov 131(1-3):38-45.
Evidence 28 Hemolysis

Activity

[Ref:15996769]LD50=30 µM against washed human erythrocytes
Hemolysis

Target

washed human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Regul Pept. 2005 Nov 131(1-3):38-45.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.