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Peptide record

TPDB07306

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07306
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLLASLFSRLF
Physicochemical Analysis
C77H118N16O16
NDCEQGHIKMTWYV
L
1523.88
11.05
1
0
9
+1
-4.84
1.654
157.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
0
K
0
M
3
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 0 M: 0 F: 3 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C77H118N16O16
1523.88
11.05
+1
-4.84
1.654
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 2 uM) (see ref). A more complete study was also conducted. Also active against S. aureus USA300
Evidence 2 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

Staphylococcus aureus USA300

Source & Reference

dbAMP DRAMP

Other

ureus (MIC 2 uM) (see ref). A more complete study was also conducted. Also active against S. aureus USA300 (MIC 1.6 uM), S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM,
Evidence 3 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

dbAMP DRAMP

Other

ore complete study was also conducted. Also active against S. aureus USA300 (MIC 1.6 uM), S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM, C. glabrata (MIC 25 uM), and C. t
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

B. subtilis 168

Source & Reference

dbAMP DRAMP

Other

ted. Also active against S. aureus USA300 (MIC 1.6 uM), S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM, C. glabrata (MIC 25 uM), and C. tropicalis (1.6-3.1 uM). HL50 =
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

C. glabrata

Source & Reference

dbAMP DRAMP

Other

S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM, C. glabrata (MIC 25 uM), and C. tropicalis (1.6-3.1 uM). HL50 = Mishra, Wang et al. 2018 ). Updated 5/2018.
Evidence 6 Activity

Activity

MIC
Antifungal
2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 2 uM) (see ref). A more complete study was also conducted. Also active against S. aureus USA300
Evidence 7 Activity

Activity

MIC
Antifungal
1.6 µM

Target

Staphylococcus aureus USA300

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ureus (MIC 2 uM) (see ref). A more complete study was also conducted. Also active against S. aureus USA300 (MIC 1.6 uM), S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM,
Evidence 8 Activity

Activity

MIC
Antifungal
1.6 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ore complete study was also conducted. Also active against S. aureus USA300 (MIC 1.6 uM), S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM, C. glabrata (MIC 25 uM), and C. t
Evidence 9 Activity

Activity

MIC
Antifungal
12.5 µM

Target

B. subtilis 168

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ted. Also active against S. aureus USA300 (MIC 1.6 uM), S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM, C. glabrata (MIC 25 uM), and C. tropicalis (1.6-3.1 uM). HL50 =
Evidence 10 Activity

Activity

MIC
Antifungal
25 µM

Target

C. glabrata

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM, C. glabrata (MIC 25 uM), and C. tropicalis (1.6-3.1 uM). HL50 = Mishra, Wang et al. 2018 ). Updated 5/2018.
Evidence 11 Activity

Activity

MIC
Antiparasitic
2 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus (MIC 2 uM) (see ref). A more complete study was also conducted. Also active against S. aureus USA300
Evidence 12 Activity

Activity

MIC
Antiparasitic
1.6 µM

Target

Staphylococcus aureus USA300

Source & Reference

DRAMP

Other

ureus (MIC 2 uM) (see ref). A more complete study was also conducted. Also active against S. aureus USA300 (MIC 1.6 uM), S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM,
Evidence 13 Activity

Activity

MIC
Antiparasitic
1.6 µM

Target

Staphylococcus epidermidis 1457

Source & Reference

DRAMP

Other

ore complete study was also conducted. Also active against S. aureus USA300 (MIC 1.6 uM), S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM, C. glabrata (MIC 25 uM), and C. t
Evidence 14 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

B. subtilis 168

Source & Reference

DRAMP

Other

ted. Also active against S. aureus USA300 (MIC 1.6 uM), S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM, C. glabrata (MIC 25 uM), and C. tropicalis (1.6-3.1 uM). HL50 =
Evidence 15 Activity

Activity

MIC
Antiparasitic
25 µM

Target

C. glabrata

Source & Reference

DRAMP

Other

S. epidermidis 1457 (MIC 1.6 uM), B. subtilis 168 (MIC 12.5 uM), C. albicans (MIC 25 uM, C. glabrata (MIC 25 uM), and C. tropicalis (1.6-3.1 uM). HL50 = Mishra, Wang et al. 2018 ). Updated 5/2018.
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
<12.5 µM
Hemolytic Cytotoxic
50% Hemolysis | <12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins. | Peptides | 2018
Evidence 17 Activity

Activity

LC50
Toxicity
50 µM
Cytotoxic
LC50 | 50 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins. | Peptides | 2018
Evidence 18 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.