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Peptide record

TPDB07301

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

13 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07301

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLIIRRPIVLGLL

FASTA

>TPDB07301|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=13
FLIIRRPIVLGLL

Formula C75H131N19O14

Absent Amino Acids ANDCEQHKMSTWY

Common Amino Acids L

Mass 1522.98

PI 12.40

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +2

Boman Index -2.15

Hydrophobicity 1.900

Aliphatic Index 232.31

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 4 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

Formula

C75H131N19O14

Mass

1522.98

12.40

Net Charge

Boman Index

-2.15

Hydrophobicity

1.900

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 30 ug/ml), S. aureus ATCC2592 (MIC 10 uM), and C. albicans ATCC2002 (MIC 12.5 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 30 ug/ml), S. aureus ATCC2592 (MIC 10 uM), and C. albicans ATCC2002 (MIC 12.5 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 30 ug/ml), S. aureus ATCC2592 (MIC 10 uM), and C. albicans ATCC2002 (MIC 12.5 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 30 ug/ml), S. aureus ATCC2592 (MIC 10 uM), and C. albicans ATCC2002 (MIC 12.5 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 30 ug/ml), S. aureus ATCC2592 (MIC 10 uM), and C. albicans ATCC2002 (MIC 12.5 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 30 ug/ml), S. aureus ATCC2592 (MIC 10 uM), and C. albicans ATCC2002 (MIC 12.5 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli ATCC25922 (MIC 30 ug/ml), S. aureus ATCC2592 (MIC 10 uM), and C. albicans ATCC2002 (MIC 12.5 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 10 µM

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 30 ug/ml), S. aureus ATCC2592 (MIC 10 uM), and C. albicans ATCC2002 (MIC 12.5 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 30 ug/ml), S. aureus ATCC2592 (MIC 10 uM), and C. albicans ATCC2002 (MIC 12.5 ug/ml).

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.16330062]Little hemolytic activity up to 50 µg/ml against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Toxicon. 2006 Feb 47(2):249-53.