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Peptide record

TPDB07299

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07299
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP DRAVP 2.0 ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LLPIVGNLLKSLL
Physicochemical Analysis
C67H121N15O16
ARDCEQHMFTWY
L
1392.79
10.10
1
0
8
+1
-1.60
1.638
232.31
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
6
L
1
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 6 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C67H121N15O16
1392.79
10.10
+1
-1.60
1.638
Evidence Records 38 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.8-7 µM

Target

m. group A

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
LC50 1.3 uM), S. aureus Cowan I (LC50 6.2 uM ), Y. pseudotubercolosis, S. pyogenes beta hem. group A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 u
Evidence 2 Activity

Activity

MIC
Antibacterial
>360 µM

Target

P.aeruginosa ATCC15692

Source & Reference

dbAMP DRAMP

Other

eudotubercolosis, S. pyogenes beta hem. group A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM)
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

oup A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM) and L. mexicana (MIC 24-64 u
Evidence 4 Activity

Activity

MIC
Antibacterial
24-64 µM

Target

L. mexicana

Source & Reference

dbAMP DRAMP

Other

d C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM) and L. mexicana (MIC 24-64 uM) (Molecules. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. co
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5-50 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

4 uM) (Molecules. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium
Evidence 6 Activity

Activity

MIC
Antibacterial
12-48 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) (
Evidence 7 Activity

Activity

MIC
Antibacterial
24 µM

Target

A. baumannii

Source & Reference

dbAMP DRAMP

Other

2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ).
Evidence 8 Activity

Activity

MIC
Antibacterial
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP DRAMP

Other

12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). Antibiofilm:bacteria: This peptide has antibiofilm abili
Evidence 9 Activity

Activity

MIC
Antifungal
2.8-7 µM

Target

m. group A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
LC50 1.3 uM), S. aureus Cowan I (LC50 6.2 uM ), Y. pseudotubercolosis, S. pyogenes beta hem. group A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 u
Evidence 10 Activity

Activity

MIC
Antifungal
>360 µM

Target

P.aeruginosa ATCC15692

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

eudotubercolosis, S. pyogenes beta hem. group A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM)
Evidence 11 Activity

Activity

MIC
Antifungal
4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

oup A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM) and L. mexicana (MIC 24-64 u
Evidence 12 Activity

Activity

MIC
Antifungal
24-64 µM

Target

L. mexicana

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

d C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM) and L. mexicana (MIC 24-64 uM) (Molecules. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. co
Evidence 13 Activity

Activity

MIC
Antifungal
12.5-50 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

4 uM) (Molecules. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium
Evidence 14 Activity

Activity

MIC
Antifungal
12-48 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) (
Evidence 15 Activity

Activity

MIC
Antifungal
24 µM

Target

A. baumannii

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ).
Evidence 16 Activity

Activity

MIC
Antifungal
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). Antibiofilm:bacteria: This peptide has antibiofilm abili
Evidence 17 Activity

Activity

MIC
Antiparasitic
2.8-7 µM

Target

m. group A

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
LC50 1.3 uM), S. aureus Cowan I (LC50 6.2 uM ), Y. pseudotubercolosis, S. pyogenes beta hem. group A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 u
Evidence 18 Activity

Activity

MIC
Antiparasitic
>360 µM

Target

P.aeruginosa ATCC15692

Source & Reference

dbAMP 3.0 DRAMP

Other

eudotubercolosis, S. pyogenes beta hem. group A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM)
Evidence 19 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP

Other

oup A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM) and L. mexicana (MIC 24-64 u
Evidence 20 Activity

Activity

MIC
Antiparasitic
24-64 µM

Target

L. mexicana

Source & Reference

dbAMP 3.0 DRAMP

Other

d C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM) and L. mexicana (MIC 24-64 uM) (Molecules. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. co
Evidence 21 Activity

Activity

MIC
Antiparasitic
12.5-50 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

4 uM) (Molecules. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium
Evidence 22 Activity

Activity

MIC
Antiparasitic
12-48 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) (
Evidence 23 Activity

Activity

MIC
Antiparasitic
24 µM

Target

A. baumannii

Source & Reference

dbAMP 3.0 DRAMP

Other

2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ).
Evidence 24 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP 3.0 DRAMP

Other

12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). Antibiofilm:bacteria: This peptide has antibiofilm abili
Evidence 25 Activity

Activity

MIC
Antiviral
2.8-7 µM

Target

m. group A

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
LC50 1.3 uM), S. aureus Cowan I (LC50 6.2 uM ), Y. pseudotubercolosis, S. pyogenes beta hem. group A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 u
Evidence 26 Activity

Activity

MIC
Antiviral
>360 µM

Target

P.aeruginosa ATCC15692

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

eudotubercolosis, S. pyogenes beta hem. group A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM)
Evidence 27 Activity

Activity

MIC
Antiviral
4 µM

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

oup A (MIC 2.8-7 uM), E. coli D21 (LC50 21 uM), P.aeruginosa ATCC15692 (MIC >360 uM), and C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM) and L. mexicana (MIC 24-64 u
Evidence 28 Activity

Activity

MIC
Antiviral
24-64 µM

Target

L. mexicana

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

d C. albicans (MIC 4 uM), including parasites L. donovani promastigotes (LC50 8.6 uM) and L. mexicana (MIC 24-64 uM) (Molecules. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. co
Evidence 29 Activity

Activity

MIC
Antiviral
12.5-50 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

4 uM) (Molecules. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium
Evidence 30 Activity

Activity

MIC
Antiviral
12-48 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) (
Evidence 31 Activity

Activity

MIC
Antiviral
24 µM

Target

A. baumannii

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

2005 Jan 14 280(2):984-90). Also E. coli (MIC 12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ).
Evidence 32 Activity

Activity

MIC
Antiviral
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

12.5-50 uM), S. aureus (MIC 12-48 uM), and A. baumannii (MIC 24 uM). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). Antibiofilm:bacteria: This peptide has antibiofilm abili
Evidence 33 Activity

Activity

5% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
5% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-Pseudomonas activity of frog skin antimicrobial peptides in a Caenorhabditis elegans infection model: a plausible mode of action in vitro and in vivo. | Antimicrob Agents Chemother | 2010
Evidence 34 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide. | Front Chem | 2017
Evidence 35 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide. | Front Chem | 2017
Evidence 36 Activity

Activity

50% Cytotoxicity
Toxicity
90.4 µg/mL
Cytotoxic
50% Cytotoxicity | 90.4 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection | Antimicrob Agents Chemother | 2018
Evidence 37 Activity

Activity

50% Cytotoxicity
Toxicity
84 µg/mL
Cytotoxic
50% Cytotoxicity | 84 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection | Antimicrob Agents Chemother | 2018
Evidence 38 Activity

Activity

% Hemolysis
Toxicity
1 %
Hemolytic
Hemolytic_activity: [Ref.9022710] LC>120 µM against Human red blood cells. (LC: Lethal concentration)##[Ref.28443279] 1% hemolysis at 96µM against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 1996 Dec 15 242(3):788-792.##Front Chem. 2017 Apr 11 5:24.