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Peptide record

TPDB07298

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07298
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLSIIAKVLGSLF
Physicochemical Analysis
C70H114N14O16
RNDCEQHMPTWY
L
1407.76
10.10
1
0
9
+1
-3.40
2.008
180.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
3
L
1
K
0
M
2
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 1 M: 0 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C70H114N14O16
1407.76
10.10
+1
-3.40
2.008
Evidence Records 28 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus aureus NCTC8325

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), E. faecalis ATCC 29212 (MIC 20
Evidence 2 Activity

Activity

MIC
Antibacterial
5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), E. faecalis ATCC 29212 (MIC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.col
Evidence 3 Activity

Activity

MIC
Antibacterial
20 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

t S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), E. faecalis ATCC 29212 (MIC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumon
Evidence 4 Activity

Activity

MIC
Antibacterial
>160 µM

Target

E.coli ATCC25922

Source & Reference

dbAMP DRAMP

Other

5 uM), E. faecalis ATCC 29212 (MIC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae H
Evidence 5 Activity

Activity

MIC
Antibacterial
>160 µM

Target

K.pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP

Other

IC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albica
Evidence 6 Activity

Activity

MIC
Antibacterial
>160 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

C 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albicans (MIC >160 uM). In vitro Toxicity: mo
Evidence 7 Activity

Activity

MIC
Antibacterial
>160 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

dbAMP DRAMP

Other

MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albicans (MIC >160 uM). In vitro Toxicity: moderate hemllytic HC50 30 uM. Updated
Evidence 8 Activity

Activity

MIC
Antibacterial
>160 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

>160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albicans (MIC >160 uM). In vitro Toxicity: moderate hemllytic HC50 30 uM. Updated 5/2020 7/2021
Evidence 9 Activity

Activity

MIC
Antifungal
5 µM

Target

Staphylococcus aureus NCTC8325

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), E. faecalis ATCC 29212 (MIC 20
Evidence 10 Activity

Activity

MIC
Antifungal
5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), E. faecalis ATCC 29212 (MIC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.col
Evidence 11 Activity

Activity

MIC
Antifungal
20 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

t S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), E. faecalis ATCC 29212 (MIC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumon
Evidence 12 Activity

Activity

MIC
Antifungal
>160 µM

Target

E.coli ATCC25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 uM), E. faecalis ATCC 29212 (MIC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae H
Evidence 13 Activity

Activity

MIC
Antifungal
>160 µM

Target

K.pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albica
Evidence 14 Activity

Activity

MIC
Antifungal
>160 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albicans (MIC >160 uM). In vitro Toxicity: mo
Evidence 15 Activity

Activity

MIC
Antifungal
>160 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albicans (MIC >160 uM). In vitro Toxicity: moderate hemllytic HC50 30 uM. Updated
Evidence 16 Activity

Activity

MIC
Antifungal
>160 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

>160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albicans (MIC >160 uM). In vitro Toxicity: moderate hemllytic HC50 30 uM. Updated 5/2020 7/2021
Evidence 17 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Staphylococcus aureus NCTC8325

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), E. faecalis ATCC 29212 (MIC 20
Evidence 18 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

DRAMP

Other

Active against S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), E. faecalis ATCC 29212 (MIC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.col
Evidence 19 Activity

Activity

MIC
Antiparasitic
20 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

t S. aureus NCTC8325 (MIC 5 uM), MRSA T7/20 (MIC 10 uM), S. epidermidis RP62A (MIC 5 uM), E. faecalis ATCC 29212 (MIC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumon
Evidence 20 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

E.coli ATCC25922

Source & Reference

DRAMP

Other

5 uM), E. faecalis ATCC 29212 (MIC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae H
Evidence 21 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

K.pneumoniae KK3 9904

Source & Reference

DRAMP

Other

IC 20 uM), Streptococcus group B HNTCC 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albica
Evidence 22 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

C 80130 (MIC 20 uM), E.coli ATCC25922 (MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albicans (MIC >160 uM). In vitro Toxicity: mo
Evidence 23 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

DRAMP

Other

MIC >160 uM), K.pneumoniae KK3 9904 (MIC >160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albicans (MIC >160 uM). In vitro Toxicity: moderate hemllytic HC50 30 uM. Updated
Evidence 24 Activity

Activity

MIC
Antiparasitic
>160 µM

Target

C.albicans

Source & Reference

DRAMP

Other

>160 uM), P.aeruginosa ATCC 27853 (MIC >160 uM), E. cloacae HNTCC 53001(MIC >160 uM), and C.albicans (MIC >160 uM). In vitro Toxicity: moderate hemllytic HC50 30 uM. Updated 5/2020 7/2021
Evidence 25 Activity

Activity

Hemolysis
[Ref:15996769]LD50=30 µM against washed human erythrocytes

Target

washed human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Regul Pept. 2005 Nov 131(1-3):38-45.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
50% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of antimicrobial peptides from the skin secretions of the carpenter frog Rana virgatipes (Ranidae, Aquarana). | Regul Pept | 2005
Evidence 27 Activity

Activity

LD50
Toxicity
30 µM
Hemolytic
Hemolytic_activity: [Ref:15996769]LD50=30 µM against washed human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Regul Pept. 2005 Nov 131(1-3):38-45.
Evidence 28 Hemolysis

Activity

[Ref:15996769]LD50=30 µM against washed human erythrocytes
Hemolysis

Target

washed human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Regul Pept. 2005 Nov 131(1-3):38-45.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.