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Peptide record

TPDB07297

Alloferon 1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07297
Alloferon 1
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP dbAMP 3.0 iACP-DRLF pep-lab Antifungipept CAFPdb DRAMP i2APP AI4AVP DRAVP 2.0 ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
HGVSGHGQHGVHG
Physicochemical Analysis
C52H76N22O16
ARNDCEILKMFPTWY
G
1265.31
8.15
4
0
2
+0
4.74
-0.823
44.62
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
5
G
4
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 4 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
13
C52H76N22O16
1265.31
8.15
+0
4.74
-0.823
Free
L
Not Available
Free
Antibacterial
Blow flyCalliphora vicina
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16-64 µg/mL

Target

Staphylococcus aureus ATCC25923 or penicillin-resistant

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
n Herpes Virus type 1 (HHV-1) multiplication ( Kuczer et al. 2011 ). Active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicilli
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Staphylococcus epidermidis penicillin-resistant

Source & Reference

dbAMP DRAMP

Other

11 ). Active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC2785
Evidence 3 Activity

Activity

MIC
Antibacterial
8-16 µg/mL

Target

Escherichia coli ATCC25922 or penicillin-resistant

Source & Reference

dbAMP DRAMP

Other

in-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC
Evidence 4 Activity

Activity

MIC
Antibacterial
8-32 µg/mL

Target

Pseudomonas aeruginosa ATCC27853 or penicillin-resistant

Source & Reference

dbAMP DRAMP

Other

sistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 16 ug/ml) ( Tu J et al., 2015 )
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Klebsiella pneumoniae ATCC13883 or penicillin-resistant

Source & Reference

dbAMP DRAMP

Other

t (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 16 ug/ml) ( Tu J et al., 2015 ).
Evidence 6 Activity

Activity

Not Available
Anticancer

Target

Skin Cancer
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2002

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 7 Activity

Activity

MIC
Antifungal
16-64 µg/mL

Target

Staphylococcus aureus ATCC25923 or penicillin-resistant

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
n Herpes Virus type 1 (HHV-1) multiplication ( Kuczer et al. 2011 ). Active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicilli
Evidence 8 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Staphylococcus epidermidis penicillin-resistant

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

11 ). Active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC2785
Evidence 9 Activity

Activity

MIC
Antifungal
8-16 µg/mL

Target

Escherichia coli ATCC25922 or penicillin-resistant

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

in-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC
Evidence 10 Activity

Activity

MIC
Antifungal
8-32 µg/mL

Target

Pseudomonas aeruginosa ATCC27853 or penicillin-resistant

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

sistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 16 ug/ml) ( Tu J et al., 2015 )
Evidence 11 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Klebsiella pneumoniae ATCC13883 or penicillin-resistant

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

t (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 16 ug/ml) ( Tu J et al., 2015 ).
Evidence 12 Activity

Activity

MIC
Antiparasitic
16-64 µg/mL

Target

Staphylococcus aureus ATCC25923 or penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class. DRAMP antiparasitic activity supported by activity records against parasitic targets.
n Herpes Virus type 1 (HHV-1) multiplication ( Kuczer et al. 2011 ). Active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicilli
Evidence 13 Activity

Activity

MIC
Antiparasitic
32 µg/mL

Target

Staphylococcus epidermidis penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP

Other

11 ). Active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC2785
Evidence 14 Activity

Activity

MIC
Antiparasitic
8-16 µg/mL

Target

Escherichia coli ATCC25922 or penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP

Other

in-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC
Evidence 15 Activity

Activity

MIC
Antiparasitic
8-32 µg/mL

Target

Pseudomonas aeruginosa ATCC27853 or penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP

Other

sistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 16 ug/ml) ( Tu J et al., 2015 )
Evidence 16 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Klebsiella pneumoniae ATCC13883 or penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP

Other

t (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 16 ug/ml) ( Tu J et al., 2015 ).
Evidence 17 Activity

Activity

MIC
Antiviral
16-64 µg/mL

Target

Staphylococcus aureus ATCC25923 or penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class. DRAMP antiviral activity supported by activity records against viral targets.
n Herpes Virus type 1 (HHV-1) multiplication ( Kuczer et al. 2011 ). Active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicilli
Evidence 18 Activity

Activity

MIC
Antiviral
32 µg/mL

Target

Staphylococcus epidermidis penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

11 ). Active against Gram+ S. aureus ATCC25923 or penicillin-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC2785
Evidence 19 Activity

Activity

MIC
Antiviral
8-16 µg/mL

Target

Escherichia coli ATCC25922 or penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

in-resistant (MIC 16-64 ug/ml), S. epidermidis penicillin-resistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC
Evidence 20 Activity

Activity

MIC
Antiviral
8-32 µg/mL

Target

Pseudomonas aeruginosa ATCC27853 or penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

sistant (MIC 32 ug/ml), Gram- E. coli ATCC25922 or penicillin-resistant (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 16 ug/ml) ( Tu J et al., 2015 )
Evidence 21 Activity

Activity

MIC
Antiviral
16 µg/mL

Target

Klebsiella pneumoniae ATCC13883 or penicillin-resistant

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

t (MIC 8-16 ug/ml), P. aeruginosa ATCC27853 or penicillin-resistant (MIC 8-32 ug/ml), and K. pneumoniae ATCC13883 or penicillin-resistant (MIC 16 ug/ml) ( Tu J et al., 2015 ).
Evidence 22 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Further studies on the antiviral activity of alloferon and its analogues. | J Pept Sci | 2011
Evidence 23 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
Further studies on the antiviral activity of alloferon and its analogues. | J Pept Sci | 2011