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Peptide record

TPDB07296

Aurein 1.1 Antibacterial Anticancer Antifungal Antiparasitic standard

13 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07296

Peptide_Name

Aurein 1.1

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLFDIIKKIAESI

FASTA

>TPDB07296|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=13
GLFDIIKKIAESI

Formula C68H115N15O19

Absent Amino Acids RNCQHMPTWYV

Common Amino Acids I

Mass 1446.75

PI 6.99

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 7

Net Charge -0

Boman Index 2.27

Hydrophobicity 0.800

Aliphatic Index 157.69

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 4 L: 1 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C68H115N15O19

Mass

1446.75

6.99

Net Charge

-0

Boman Index

2.27

Hydrophobicity

0.800

C_terminal_Modification

Free

Chirality

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Anticancer

Origin

Litoria aureaandLitoria raniformis, Australia

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus (MIC > 100 ug/ml), P.mult

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus (MIC > 100 ug/ml), P.multocida (MIC > 100 ug/ml), S

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

tive against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus (MIC > 100 ug/ml), P.multocida (MIC > 100 ug/ml), S.aureus (MIC > 100 ug/ml), S

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ocida (MIC > 100 ug/ml), S.aureus (MIC > 100 ug/ml), S.epidermidis (MIC > 100 ug/ml), and S. uberis (MIC 100 ug/ml) (provided by Chunfeng Wang, validated GW). Derivative: The peptide shows anticancer activ

Evidence 6 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Not Available

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2000

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus (MIC > 100 ug/ml), P.mult

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus (MIC > 100 ug/ml), P.multocida (MIC > 100 ug/ml), S

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µg/mL

Target

Target Organism B. cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus (MIC > 100 ug/ml), P.mult

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism L. lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. cereus (MIC 50 ug/ml), E.coli (MIC >100 ug/ml), L. lactis (MIC 25 ug/ml), L. innocua (MIC 100 ug/ml), M.luteus (MIC > 100 ug/ml), P.multocida (MIC > 100 ug/ml), S

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism L. innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism S. uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text