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Peptide record

TPDB07282

Antibacterial Antifungal Toxicity standard

13 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB07282

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ILKWKWPWWPWRR

FASTA

>TPDB07282|Antibacterial;Antifungal;Toxicity|length=13
ILKWKWPWWPWRR

Formula C101H136N26O14

Absent Amino Acids ANDCEQGHMFSTYV

Common Amino Acids W

Mass 1938.36

PI 12.42

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +4

Boman Index -5.62

Hydrophobicity -1.246

Aliphatic Index 60.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 27500

Absorbance 280nm 1418.73

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 5 Y: 0 V: 0

Length

Formula

C101H136N26O14

Mass

1938.36

12.42

Net Charge

Boman Index

-5.62

Hydrophobicity

-1.246

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against P. aeruginosa PAO1 (MIC 16 ug/ml), E. coli (MIC 8 ug/ml), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epider

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against P. aeruginosa PAO1 (MIC 16 ug/ml), E. coli (MIC 8 ug/ml), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 31 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against P. aeruginosa PAO1 (MIC 16 ug/ml), E. coli (MIC 8 ug/ml), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E. faecalis ATCC29212 (MIC 31 ug/

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

P. aeruginosa PAO1 (MIC 16 ug/ml), E. coli (MIC 8 ug/ml), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E. faecalis ATCC29212 (MIC 31 ug/ml), and C. albicans (MIC

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

16 ug/ml), E. coli (MIC 8 ug/ml), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E. faecalis ATCC29212 (MIC 31 ug/ml), and C. albicans (MIC 8 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 31 µg/mL

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

l), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E. faecalis ATCC29212 (MIC 31 ug/ml), and C. albicans (MIC 8 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

us (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E. faecalis ATCC29212 (MIC 31 ug/ml), and C. albicans (MIC 8 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against P. aeruginosa PAO1 (MIC 16 ug/ml), E. coli (MIC 8 ug/ml), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epider

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

active against P. aeruginosa PAO1 (MIC 16 ug/ml), E. coli (MIC 8 ug/ml), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E.

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 31 µg/mL

Target

Target Organism S. typhimurium

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

active against P. aeruginosa PAO1 (MIC 16 ug/ml), E. coli (MIC 8 ug/ml), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E. faecalis ATCC29212 (MIC 31 ug/

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

16 ug/ml), E. coli (MIC 8 ug/ml), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E. faecalis ATCC29212 (MIC 31 ug/ml), and C. albicans (MIC 8 ug/ml).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 31 µg/mL

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

l), S. typhimurium (MIC 31 ug/ml), S. aureus (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E. faecalis ATCC29212 (MIC 31 ug/ml), and C. albicans (MIC 8 ug/ml).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

us (MIC 8 ug/ml), S. epidermidis (MIC 4 ug/ml), E. faecalis ATCC29212 (MIC 31 ug/ml), and C. albicans (MIC 8 ug/ml).

Evidence 15 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 400 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity | Peptides | 2009

Evidence 16 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Toxicity

Activity Measurement 400 µg/mL

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.19428758] HC50=400 µg/ml against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2009 May 30(5):832-8. doi: 10.1016/j.peptides.2009.01.015.