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Peptide record

TPDB07279

Anti-inflammatory Antibacterial Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07279
Anti-inflammatory Antibacterial Antifungal Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 dbAMP DRAMP Antifungipept
standard
No
A 13-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, dbAMP, and other sources, with an available 3D structural model.
Sequence
GKIIKLKASLKLL
Physicochemical Analysis
C68H129N17O15
RNDCEQHMFPTWYV
LK
1424.88
11.00
4
0
7
+4
1.07
0.708
187.69
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
4
L
4
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 4 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C68H129N17O15
1424.88
11.00
+4
1.07
0.708
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Its lysine analog, GL13K, however, is active against P. aeruginosa (MIC 8 ug/ml), E. coli (MIC 5 ug/ml), S. gordonii (MIC 64 ug/ml) and S. aureus (MIC 41 ug/ml) ( Harmouc
Evidence 2 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Its lysine analog, GL13K, however, is active against P. aeruginosa (MIC 8 ug/ml), E. coli (MIC 5 ug/ml), S. gordonii (MIC 64 ug/ml) and S. aureus (MIC 41 ug/ml) ( Harmouche N et al., 2017 ). GL
Evidence 3 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

S. gordonii

Source & Reference

dbAMP DRAMP

Other

og, GL13K, however, is active against P. aeruginosa (MIC 8 ug/ml), E. coli (MIC 5 ug/ml), S. gordonii (MIC 64 ug/ml) and S. aureus (MIC 41 ug/ml) ( Harmouche N et al., 2017 ). GL13K also has antibiofilm act
Evidence 4 Activity

Activity

MIC
Antibacterial
41 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

gainst P. aeruginosa (MIC 8 ug/ml), E. coli (MIC 5 ug/ml), S. gordonii (MIC 64 ug/ml) and S. aureus (MIC 41 ug/ml) ( Harmouche N et al., 2017 ). GL13K also has antibiofilm activity against P. aeruginosa (
Evidence 5 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Its lysine analog, GL13K, however, is active against P. aeruginosa (MIC 8 ug/ml), E. coli (MIC 5 ug/ml), S. gordonii (MIC 64 ug/ml) and S. aureus (MIC 41 ug/ml) ( Harmouc
Evidence 6 Activity

Activity

MIC
Antifungal
5 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Its lysine analog, GL13K, however, is active against P. aeruginosa (MIC 8 ug/ml), E. coli (MIC 5 ug/ml), S. gordonii (MIC 64 ug/ml) and S. aureus (MIC 41 ug/ml) ( Harmouche N et al., 2017 ). GL
Evidence 7 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

S. gordonii

Source & Reference

dbAMP DRAMP Antifungipept

Other

og, GL13K, however, is active against P. aeruginosa (MIC 8 ug/ml), E. coli (MIC 5 ug/ml), S. gordonii (MIC 64 ug/ml) and S. aureus (MIC 41 ug/ml) ( Harmouche N et al., 2017 ). GL13K also has antibiofilm act
Evidence 8 Activity

Activity

MIC
Antifungal
41 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

gainst P. aeruginosa (MIC 8 ug/ml), E. coli (MIC 5 ug/ml), S. gordonii (MIC 64 ug/ml) and S. aureus (MIC 41 ug/ml) ( Harmouche N et al., 2017 ). GL13K also has antibiofilm activity against P. aeruginosa (
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K. | PLoS One | 2019
Evidence 10 Activity

Activity

50% Cell death
Toxicity
500 µg/mL
Cytotoxic
50% Cell death | 500 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K. | PLoS One | 2019
Evidence 11 Activity

Activity

LD50
Toxicity
560 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31071184] LD50=560µg/ml against human blood cells | Cytotoxicity: [Ref.31071184] The cytotoxicity of L-GL13K on HEK cells is 2.1%, 3.3%, 2.4%, 1.2%24.3%, 51.7% and 73.6% at peptide concentrations of 1, 3.9, 15.6, 62.5, 250 and 1000 µg/mL, while the cytotoxicity of PMX on HEK cells (Control samples) is 1.2%, 1.2%, 6.6%, 3.6%, 39.6%, 47.1% and 68.5% at peptide concentrations of 1, 3.9, 15.6, 62.5, 250 and 1000 µg/mL.

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2019 May 9 14(5):e0216669. doi: 10.1371/journal.pone.0216669. eCollection 2019.