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Peptide record

TPDB07273

Antibacterial Anticancer Antifungal Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07273
Antibacterial Anticancer Antifungal Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 dbACP iACP-DRLF Antifungipept CAFPdb dbAMP 3.0 APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPIVAKLLSGLL
Physicochemical Analysis
C69H118N14O15
RNDCEQHMTWY
L
1383.78
10.10
1
0
9
+1
-2.76
1.969
210.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
5
L
1
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 5 K: 1 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C69H118N14O15
1383.78
10.10
+1
-2.76
1.969
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM). It also showed cytotoxic effects on
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM). It also showed cytotoxic effects on cancer cells NCI-H157, U
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

st S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM). It also showed cytotoxic effects on cancer cells NCI-H157, U251MG, PC-3, MDA-MB-435s wit
Evidence 5 Activity

Activity

MIC
Antifungal
2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
16 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM). It also showed cytotoxic effects on
Evidence 7 Activity

Activity

MIC
Antifungal
8 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM). It also showed cytotoxic effects on cancer cells NCI-H157, U
Evidence 8 Activity

Activity

MIC
Antifungal
4 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

st S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM). It also showed cytotoxic effects on cancer cells NCI-H157, U251MG, PC-3, MDA-MB-435s wit
Evidence 9 Activity

Activity

MIC
Antiviral
2 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM).
Evidence 10 Activity

Activity

MIC
Antiviral
16 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM). It also showed cytotoxic effects on
Evidence 11 Activity

Activity

MIC
Antiviral
8 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM). It also showed cytotoxic effects on cancer cells NCI-H157, U
Evidence 12 Activity

Activity

MIC
Antiviral
4 µM

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP

Other

st S. aureus (MIC 2 uM), MRSA (MIC 4 uM) E. coli (MIC 16 uM), E. faecalis (MIC 8 uM), and C. albicans (MIC 4 uM). It also showed cytotoxic effects on cancer cells NCI-H157, U251MG, PC-3, MDA-MB-435s wit
Evidence 13 Activity

Activity

HC50
Hemolysis
39.64 µM
[Ref.29191658]HC50=39.64 µM against horse red blood cells

Target

horse red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochem Biophys Res Commun. 2018 Jan 22 495(4):2539-2546.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

IC50
Toxicity
58.62 µM
Cytotoxic
IC50 | 58.62 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Identification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. esculentus. | Biochem Biophys Res Commun | 2017
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
39.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 39.6 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Identification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. esculentus. | Biochem Biophys Res Commun | 2017
Evidence 16 Activity

Activity

10% Hemolysis
Toxicity
12.53 µM
Hemolytic Cytotoxic
10% Hemolysis | 12.53 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies. | J Med Chem | 2022
Evidence 17 Activity

Activity

50% Cytotoxicity
Toxicity
35.85 µM
Cytotoxic
50% Cytotoxicity | 35.85 | µM | target cell: Human glomerular mesangial cells (GMC)

Target

Human glomerular mesangial cells (GMC)

Source & Reference

NA
DBAASP
Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies. | J Med Chem | 2022
Evidence 18 Activity

Activity

50% Cytotoxicity
Toxicity
32 µM
Cytotoxic
50% Cytotoxicity | 32 | µM | target cell: Human kidney proximal tubule HK-2 cells

Target

Human kidney proximal tubule HK-2 cells

Source & Reference

NA
DBAASP
Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies. | J Med Chem | 2022
Evidence 19 Activity

Activity

HC50
Toxicity
39.64 µM
Hemolytic
Hemolytic_activity: [Ref.29191658]HC50=39.64 µM against horse red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2018 Jan 22 495(4):2539-2546.
Evidence 20 Hemolysis

Activity

39.64 µM
HC50
[Ref.29191658]HC50=39.64 µM against horse red blood cells
Hemolysis

Target

horse red blood cells

Source & Reference

APD_complete PD_Hemolysis
Biochem Biophys Res Commun. 2018 Jan 22 495(4):2539-2546.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.