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Peptide record

TPDB07258

Antibacterial Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07258
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ILAWKWAWWAWRR
Physicochemical Analysis
C94H125N25O14
NDCEQGHMFPSTYV
W
1829.19
12.41
3
0
10
+3
-8.02
-0.285
83.08
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
27500
1503.40
0
Residue Composition
number
3
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
13
C94H125N25O14
1829.19
12.41
+3
-8.02
-0.285
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Toxicity
77.8±12.9 µM
Cytotoxic
IC50 | 77.8±12.9 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Enhanced Synergism and Mechanism of Action Studies of Synthetic Antimicrobial Metallopeptides | ChemMedChem | 2021