TPDB

3D PDB MODEL

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TPDB ID TPDB07254

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLGGLLASLLGKI

FASTA

>TPDB07254|Antibacterial;Antifungal|length=13
FLGGLLASLLGKI

Formula C63H108N14O15

Absent Amino Acids RNDCEQHMPTWYV

Common Amino Acids L

Mass 1301.64

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +1

Boman Index -3.26

Hydrophobicity 1.708

Aliphatic Index 187.69

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

3

G

0

H

1

I

5

L

1

K

0

M

1

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 5 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

13

Formula

C63H108N14O15

Mass

1301.64

PI

10.10

Net Charge

+1

Boman Index

-3.26

Hydrophobicity

1.708

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 25 ug/ml), S. aureus ATCC2592 (3.1 ug/ml), B. subtilis ATCC 6633 (3.1 ug/ml), and C. albicans ATCC2

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.6 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

22 (MIC 25 ug/ml), S. aureus ATCC2592 (3.1 ug/ml), B. subtilis ATCC 6633 (3.1 ug/ml), and C. albicans ATCC2002 (MIC 1.6 ug/ml). Updated 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 25 ug/ml), S. aureus ATCC2592 (3.1 ug/ml), B. subtilis ATCC 6633 (3.1 ug/ml), and C. albicans ATCC2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.6 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

22 (MIC 25 ug/ml), S. aureus ATCC2592 (3.1 ug/ml), B. subtilis ATCC 6633 (3.1 ug/ml), and C. albicans ATCC2002 (MIC 1.6 ug/ml). Updated 7/2021