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Peptide record

TPDB07247

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07247
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ILSAIWSGIKSLF
Physicochemical Analysis
C70H111N15O17
RNDCEQHMPTYV
IS
1434.74
10.10
1
0
8
+1
-3.81
1.392
157.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
383.34
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
2
L
1
K
0
M
1
F
0
P
3
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 1 M: 0 F: 1 P: 0 S: 3 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C70H111N15O17
1434.74
10.10
+1
-3.81
1.392
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6-15 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus, P. aeruginosa, and E. coli (MIC 6-15 uM). UyCT3 shares 100% homology with OcyC1 from O. cayaporum (Ischnuridae). Active against C.
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP

Other

M). UyCT3 shares 100% homology with OcyC1 from O. cayaporum (Ischnuridae). Active against C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 25 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neo
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP

Other

ith OcyC1 from O. cayaporum (Ischnuridae). Active against C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 25 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 u
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP

Other

idae). Active against C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 25 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activ
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP

Other

25 uM), C. tropicalis ATCC 750 (MIC 25 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activity against initial adherence of C. albicans at 10
Evidence 6 Activity

Activity

MIC
Antifungal
6-15 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus, P. aeruginosa, and E. coli (MIC 6-15 uM). UyCT3 shares 100% homology with OcyC1 from O. cayaporum (Ischnuridae). Active against C.
Evidence 7 Activity

Activity

MIC
Antifungal
25 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M). UyCT3 shares 100% homology with OcyC1 from O. cayaporum (Ischnuridae). Active against C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 25 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neo
Evidence 8 Activity

Activity

MIC
Antifungal
25 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ith OcyC1 from O. cayaporum (Ischnuridae). Active against C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 25 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 u
Evidence 9 Activity

Activity

MIC
Antifungal
25 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

idae). Active against C. albicans SC5314 (MIC 25 uM), C. tropicalis ATCC 750 (MIC 25 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activ
Evidence 10 Activity

Activity

MIC
Antifungal
12.5 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

25 uM), C. tropicalis ATCC 750 (MIC 25 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activity against initial adherence of C. albicans at 10
Evidence 11 Activity

Activity

% Hemolysis
Hemolysis
30 90 92 90 %
[Ref.23182832]30% hemolytic activity at 12.5 µM, 90% hemolytic activity at 25 µM, 92% hemolytic activity at 50 µM, 90% hemolytic activity at 100 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Toxicon. 2013 Mar 1 63:44-54.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 12 Activity

Activity

20% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
20% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 13 Activity

Activity

35% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
35% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 14 Activity

Activity

5% Hemolysis
Toxicity
6 µM
Hemolytic Cytotoxic
5% Hemolysis | 6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 15 Activity

Activity

95% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
95% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: Molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity. | Toxicon | 2013
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
17.3±0.8 µM
Hemolytic Cytotoxic
50% Hemolysis | 17.3±0.8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane interactions and biological activity of antimicrobial peptides from Australian scorpion. | Biochim Biophys Acta | 2014
Evidence 17 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23182832]30% hemolytic activity at 12.5 µM, 90% hemolytic activity at 25 µM, 92% hemolytic activity at 50 µM, 90% hemolytic activity at 100 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2013 Mar 1 63:44-54.
Evidence 18 Hemolysis

Activity

30 90 92 90 %
% Hemolysis
[Ref.23182832]30% hemolytic activity at 12.5 µM, 90% hemolytic activity at 25 µM, 92% hemolytic activity at 50 µM, 90% hemolytic activity at 100 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete PD_Hemolysis
Toxicon. 2013 Mar 1 63:44-54.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.