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Peptide record

TPDB07243

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07243
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AAGKGLVSNLLEK
Physicochemical Analysis
C57H102N16O18
RDCQHIMFPTWY
L
1299.53
9.88
2
1
6
+1
2.62
0.215
127.69
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
0
Q
2
G
0
H
0
I
3
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 3 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C57H102N16O18
1299.53
9.88
+1
2.62
0.215
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
24.6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 (MIC 24.6 uM) and S. aureus ATCC 25923 (MIC 49 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
49 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 (MIC 24.6 uM) and S. aureus ATCC 25923 (MIC 49 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
24.6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 (MIC 24.6 uM) and S. aureus ATCC 25923 (MIC 49 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
49 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 24.6 uM) and S. aureus ATCC 25923 (MIC 49 uM).
Evidence 5 Activity

Activity

0% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
0% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides. | Molecules | 2018
Evidence 6 Activity

Activity

28% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
28% Hemolysis | 160 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides. | Molecules | 2018
Evidence 7 Activity

Activity

100% Hemolysis
Toxicity
320 µM
Hemolytic Cytotoxic
100% Hemolysis | 320 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides. | Molecules | 2018
Evidence 8 Activity

Activity

MHC
Toxicity
320 µM
Hemolytic
Hemolytic_activity: [Ref.30423858] 100% hemolysis MHC=320µM against human blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2018 Nov 23(11): 2943. Published online 2018 Nov 11. doi: 10.3390/molecules23112943
Evidence 9 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.