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Peptide record

TPDB07236

Antibacterial Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07236
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RRWPWWPWKWPLI
Physicochemical Analysis
C100H131N25O14
ANDCEQGHMFSTYV
W
1907.30
12.41
3
0
7
+3
-6.16
-1.069
60.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
27500
1441.83
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
3
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 3 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
13
C100H131N25O14
1907.30
12.41
+3
-6.16
-1.069
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.56 µg/mL

Target

B. subtilis IFO 3513

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ B. subtilis IFO 3513 (MIC 1.56 ug/ml), S. aureus IFO 12732 (MIC 1.56 ug/ml), and Gram- E. coli IFO 12734 (MIC 12.5 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
1.56 µg/mL

Target

Staphylococcus aureus IFO 12732

Source & Reference

dbAMP

Other

Active against Gram+ B. subtilis IFO 3513 (MIC 1.56 ug/ml), S. aureus IFO 12732 (MIC 1.56 ug/ml), and Gram- E. coli IFO 12734 (MIC 12.5 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Escherichia coli IFO 12734

Source & Reference

dbAMP

Other

m+ B. subtilis IFO 3513 (MIC 1.56 ug/ml), S. aureus IFO 12732 (MIC 1.56 ug/ml), and Gram- E. coli IFO 12734 (MIC 12.5 ug/ml).
Evidence 4 Activity

Activity

36% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
36% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of indolicidin, a Trp-rich antibacterial peptide. | J Pept Sci | 2010
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis