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Peptide record

TPDB07219

Antibacterial Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07219
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia CAFPdb
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ILPYKYPYYPYRR
Physicochemical Analysis
C90H126N20O19
ANDCEQGHMFSTWV
Y
1792.11
9.94
3
0
7
+3
-1.61
-1.223
60.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
7450
415.71
5
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
3
P
0
S
0
T
0
W
5
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 5 V: 0
Chemical Descriptors
13
C90H126N20O19
1792.11
9.94
+3
-1.61
-1.223
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

B. subtilis IFO 3513

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ B. subtilis IFO 3513 (MIC 25 ug/ml), S. aureus IFO 12732 (MIC 25 ug/ml), and Gram- E.coli IFO 12734 (MIC >100 ug/ml). Warning
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Staphylococcus aureus IFO 12732

Source & Reference

dbAMP

Other

Active against Gram+ B. subtilis IFO 3513 (MIC 25 ug/ml), S. aureus IFO 12732 (MIC 25 ug/ml), and Gram- E.coli IFO 12734 (MIC >100 ug/ml). Warning: other bacteria not tested.
Evidence 3 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

E.coli IFO 12734

Source & Reference

dbAMP

Other

Gram+ B. subtilis IFO 3513 (MIC 25 ug/ml), S. aureus IFO 12732 (MIC 25 ug/ml), and Gram- E.coli IFO 12734 (MIC >100 ug/ml). Warning: other bacteria not tested.
Evidence 4 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

B. subtilis IFO 3513

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ B. subtilis IFO 3513 (MIC 25 ug/ml), S. aureus IFO 12732 (MIC 25 ug/ml), and Gram- E.coli IFO 12734 (MIC >100 ug/ml). Warning
Evidence 5 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Staphylococcus aureus IFO 12732

Source & Reference

dbAMP CAFPdb

Other

Active against Gram+ B. subtilis IFO 3513 (MIC 25 ug/ml), S. aureus IFO 12732 (MIC 25 ug/ml), and Gram- E.coli IFO 12734 (MIC >100 ug/ml). Warning: other bacteria not tested.
Evidence 6 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

E.coli IFO 12734

Source & Reference

dbAMP CAFPdb

Other

Gram+ B. subtilis IFO 3513 (MIC 25 ug/ml), S. aureus IFO 12732 (MIC 25 ug/ml), and Gram- E.coli IFO 12734 (MIC >100 ug/ml). Warning: other bacteria not tested.
Evidence 7 Activity

Activity

4% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
4% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of indolicidin, a Trp-rich antibacterial peptide. | J Pept Sci | 2010
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Indolicidin analogs with broad-spectrum antimicrobial activity and low hemolytic activity | Peptides | 2020