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Peptide record

TPDB07190

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07190
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGGLIKWWPWRR
Physicochemical Analysis
C87H123N23O14
ANDCEQHMSTYV
W
1715.08
12.41
3
0
7
+3
-5.03
-0.238
90.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
16500
962.05
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
1
K
0
M
1
F
1
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
13
C87H123N23O14
1715.08
12.41
+3
-5.03
-0.238
Evidence Records 5 records
Evidence 1 Activity

Activity

75% hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
75% hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
15.62 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 15.62 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 4 Activity

Activity

50% Cell death
Toxicity
100 µg/mL
Cytotoxic
50% Cell death | 100 | µg/mL | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26046345] The hemolytic activities of RN7-IN6 is 0.0% at 15.62µg/ml against human RBCs. | Cytotoxicity: [Ref.26046345] The cell viability of NL-20 cell line is not affected (<10%) below 31.25 µg/ml. The cell viability of NL-20 is 70%, 6% and 8% at peptide concentrations of 62.5, 125 and 250 µg/ml.## The cell viability of WRL-68 cell line is not affected

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2015 Jun 5 10(6):e0128532.