Back to search

Peptide record

TPDB07186

Antibacterial Anticancer Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB07186
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb dbAMP
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
AFGMALKLLKKVL
Physicochemical Analysis
C69H122N16O14S1
RNDCEQHIPSTWY
L
1431.89
10.84
3
0
9
+3
-0.89
1.200
157.69
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
4
L
3
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C69H122N16O14S1
1431.89
10.84
+3
-0.89
1.200
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
241 µM
Hemolytic Cytotoxic
50% Hemolysis | 241 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 2 Activity

Activity

IC50
Toxicity
30±4 µM
Cytotoxic
IC50 | 30±4 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 3 Activity

Activity

IC50
Toxicity
29±7 µM
Cytotoxic
IC50 | 29±7 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 4 Activity

Activity

IC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: IC50>200 µM | Cytotoxicity: HUVEC: IC50=30±4 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jan 33(1):18-26.