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Peptide record

TPDB07183

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07183
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VRRFAWWWAFLRR
Physicochemical Analysis
C92H128N28O14
NDCEQGHIKMPSTY
R
1850.21
12.88
4
0
9
+4
-5.40
-0.269
67.69
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
16500
891.79
0
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
2
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
13
C92H128N28O14
1850.21
12.88
+4
-5.40
-0.269
Evidence Records 5 records
Evidence 1 Activity

Activity

63% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
63% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Conformation-dependent antibiotic activity of tritrpticin, a cathelicidin-derived antimicrobial peptide | Biochem Biophys Res Commun | 2002
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
60 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 60 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-function analysis of tritrpticin analogs: potential relationships between antimicrobial activities, model membrane interactions, and their micelle-bound NMR structures. | Biophys J | 2006
Evidence 3 Activity

Activity

IC50
Toxicity
20.7 µM
Cytotoxic
IC50 | 20.7 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
18 %
Hemolytic
Hemolytic_activity: [Ref.12207877]18% hemolysis at 25 µg/ml, 30% hemolysis at 50 µg/ml, 62% hemolysis at 100 µg/ml, 95% hemolysis at 200 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2002 Sep 6 296(5):1044-50.
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis