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Peptide record

TPDB07181

Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07181
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RIWFQNRRMRWRR
Physicochemical Analysis
C87H137N35O16S1
ADCEGHLKPSTYV
R
1961.33
13.10
6
0
5
+6
0.49
-2.046
30.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
560.84
2
Residue Composition
number
0
A
6
R
1
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
13
C87H137N35O16S1
1961.33
13.10
+6
0.49
-2.046
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure. | Biochim Biophys Acta | 2013
Evidence 2 Activity

Activity

HC50
Toxicity
128 µM
Hemolytic
Hemolytic_activity: [Ref.23085001] HC50>128 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2013 Feb 1828(2):223-232. doi: 10.1016/j.bbamem.2012.10.010.