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Peptide record

TPDB07171

Antibacterial Anticancer Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07171
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GLFDIWKWWRWRR
Physicochemical Analysis
C95H129N27O16
ANCEQHMPSTYV
W
1905.24
12.12
4
1
7
+3
-4.74
-1.062
60.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
22000
1154.71
0
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
1
K
0
M
1
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
13
C95H129N27O16
1905.24
12.12
+3
-4.74
-1.062
Evidence Records 5 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
52.7±5.5 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 52.7±5.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin. | Sci Rep | 2015
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>250 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin. | Sci Rep | 2015
Evidence 3 Activity

Activity

50% Cell death
Toxicity
68.5±11.0 µg/mL
Cytotoxic
50% Cell death | 68.5±11.0 | µg/mL | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin. | Sci Rep | 2015
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:10% Hemolysis=52.7±5.5µg/ml 50% Hemolysis>250µg/ml | Cytotoxicity: NL20: 50% Cell death=68.5±11.0µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2015 May 18 5:9761.
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis