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Peptide record

TPDB07168

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07168
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GLFDIWAWWRWRR
Physicochemical Analysis
C92H122N26O16
NCEQHKMPSTYV
W
1848.15
12.10
3
1
8
+2
-5.90
-0.623
67.69
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
22000
1190.38
0
Residue Composition
number
1
A
3
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
13
C92H122N26O16
1848.15
12.10
+2
-5.90
-0.623
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
114.3±26.1 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 114.3±26.1 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin. | Sci Rep | 2015
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>250 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin. | Sci Rep | 2015
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>250 µg/mL
Cytotoxic
50% Cell death | >250 | µg/mL | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin. | Sci Rep | 2015
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:10% Hemolysis=114.3±26.1µg/ml 50% Hemolysis>250µg/ml | Cytotoxicity: NL20: 50% Cell death>250µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2015 May 18 5:9761.