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Peptide record

TPDB07166

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07166
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLQHIIGALSHFF
Physicochemical Analysis
C76H108N18O16
RNDCEKMPTWYV
F
1529.80
8.00
2
0
8
+0
-2.66
1.208
127.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
2
H
2
I
2
L
0
K
0
M
3
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 2 I: 2 L: 2 K: 0 M: 0 F: 3 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C76H108N18O16
1529.80
8.00
+0
-2.66
1.208
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.7 µM

Target

Staphylococcus aureus ATCC 43300 MRSA or ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+, Gram- bacteria and fungi. Active against Gram+ S. aureus ATCC 43300 MRSA or ATCC 25923 (MIC 12.7 uM) B.subtilis ATCC 6633 (MIC 102.3 uM) Gram- E. coli ATCC 25922 or D31 (12.7-25.5 uM) V.
Evidence 2 Activity

Activity

MIC
Antibacterial
102.3 µM

Target

B.subtilis ATCC 6633

Source & Reference

dbAMP

Other

ia and fungi. Active against Gram+ S. aureus ATCC 43300 MRSA or ATCC 25923 (MIC 12.7 uM) B.subtilis ATCC 6633 (MIC 102.3 uM) Gram- E. coli ATCC 25922 or D31 (12.7-25.5 uM) V. alginolyticus IS (MIC 12.7 uM) P. ae
Evidence 3 Activity

Activity

MIC
Antibacterial
12.7 µM

Target

V. alginolyticus IS

Source & Reference

dbAMP

Other

uM) B.subtilis ATCC 6633 (MIC 102.3 uM) Gram- E. coli ATCC 25922 or D31 (12.7-25.5 uM) V. alginolyticus IS (MIC 12.7 uM) P. aeruginosa ATCC 15442 (MIC 51 uM) and C. albicans ATCC 10231 (MIC 25.5 uM). The pept
Evidence 4 Activity

Activity

MIC
Antibacterial
51 µM

Target

Pseudomonas aeruginosa ATCC 15442

Source & Reference

dbAMP

Other

3 uM) Gram- E. coli ATCC 25922 or D31 (12.7-25.5 uM) V. alginolyticus IS (MIC 12.7 uM) P. aeruginosa ATCC 15442 (MIC 51 uM) and C. albicans ATCC 10231 (MIC 25.5 uM). The peptide is also active against S. mutans (
Evidence 5 Activity

Activity

MIC
Antibacterial
25.5 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP

Other

.7-25.5 uM) V. alginolyticus IS (MIC 12.7 uM) P. aeruginosa ATCC 15442 (MIC 51 uM) and C. albicans ATCC 10231 (MIC 25.5 uM). The peptide is also active against S. mutans (MIC 13.1 uM) biofilms(MBIC50 6.6 uM) (Zhon
Evidence 6 Activity

Activity

MIC
Antibacterial
13.1 µM

Target

S. mutans

Source & Reference

dbAMP

Other

(MIC 51 uM) and C. albicans ATCC 10231 (MIC 25.5 uM). The peptide is also active against S. mutans (MIC 13.1 uM) biofilms(MBIC50 6.6 uM) (Zhong et al. et al., 2019) .
Evidence 7 Activity

Activity

MIC
Antifungal
12.7 µM

Target

Staphylococcus aureus ATCC 43300 MRSA or ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+, Gram- bacteria and fungi. Active against Gram+ S. aureus ATCC 43300 MRSA or ATCC 25923 (MIC 12.7 uM) B.subtilis ATCC 6633 (MIC 102.3 uM) Gram- E. coli ATCC 25922 or D31 (12.7-25.5 uM) V.
Evidence 8 Activity

Activity

MIC
Antifungal
102.3 µM

Target

B.subtilis ATCC 6633

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ia and fungi. Active against Gram+ S. aureus ATCC 43300 MRSA or ATCC 25923 (MIC 12.7 uM) B.subtilis ATCC 6633 (MIC 102.3 uM) Gram- E. coli ATCC 25922 or D31 (12.7-25.5 uM) V. alginolyticus IS (MIC 12.7 uM) P. ae
Evidence 9 Activity

Activity

MIC
Antifungal
12.7 µM

Target

V. alginolyticus IS

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM) B.subtilis ATCC 6633 (MIC 102.3 uM) Gram- E. coli ATCC 25922 or D31 (12.7-25.5 uM) V. alginolyticus IS (MIC 12.7 uM) P. aeruginosa ATCC 15442 (MIC 51 uM) and C. albicans ATCC 10231 (MIC 25.5 uM). The pept
Evidence 10 Activity

Activity

MIC
Antifungal
51 µM

Target

Pseudomonas aeruginosa ATCC 15442

Source & Reference

dbAMP CAFPdb Antifungipept

Other

3 uM) Gram- E. coli ATCC 25922 or D31 (12.7-25.5 uM) V. alginolyticus IS (MIC 12.7 uM) P. aeruginosa ATCC 15442 (MIC 51 uM) and C. albicans ATCC 10231 (MIC 25.5 uM). The peptide is also active against S. mutans (
Evidence 11 Activity

Activity

MIC
Antifungal
25.5 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

.7-25.5 uM) V. alginolyticus IS (MIC 12.7 uM) P. aeruginosa ATCC 15442 (MIC 51 uM) and C. albicans ATCC 10231 (MIC 25.5 uM). The peptide is also active against S. mutans (MIC 13.1 uM) biofilms(MBIC50 6.6 uM) (Zhon
Evidence 12 Activity

Activity

MIC
Antifungal
13.1 µM

Target

S. mutans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 51 uM) and C. albicans ATCC 10231 (MIC 25.5 uM). The peptide is also active against S. mutans (MIC 13.1 uM) biofilms(MBIC50 6.6 uM) (Zhong et al. et al., 2019) .
Evidence 13 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human oral epithelial cells

Target

Human oral epithelial cells

Source & Reference

NA
DBAASP
Antibacterial and Antibiofilm Activity of Temporin-GHc and Temporin-GHd Against Cariogenic Bacteria, Streptococcus mutans. | Front Microbiol | 2019
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
50% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and Antibiofilm Activity of Temporin-GHc and Temporin-GHd Against Cariogenic Bacteria, Streptococcus mutans. | Front Microbiol | 2019
Evidence 15 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.