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Peptide record

TPDB07165

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07165
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FLQHIIGALGHLF
Physicochemical Analysis
C72H108N18O15
RNDCEKMPSTWYV
L
1465.76
8.00
2
0
8
+0
-2.21
1.315
157.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
2
G
2
H
2
I
3
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 2 I: 2 L: 3 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C72H108N18O15
1465.76
8.00
+0
-2.21
1.315
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
106.8 µM

Target

B.subtilis ATCC 6633

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus ATCC 43300, MRSA or ATCC 25923 (MIC 6.8-26.6 uM) B.subtilis ATCC 6633 (MIC 106.8 uM), P. gingivalis ATCC 33277 (MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

P. gingivalis ATCC 33277

Source & Reference

dbAMP

Other

us ATCC 43300, MRSA or ATCC 25923 (MIC 6.8-26.6 uM) B.subtilis ATCC 6633 (MIC 106.8 uM), P. gingivalis ATCC 33277 (MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

B. adolescentis ATCC 15703

Source & Reference

dbAMP

Other

.8-26.6 uM) B.subtilis ATCC 6633 (MIC 106.8 uM), P. gingivalis ATCC 33277 (MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC
Evidence 4 Activity

Activity

MIC
Antibacterial
100 µM

Target

B. breve ATCC 15700

Source & Reference

dbAMP

Other

06.8 uM), P. gingivalis ATCC 33277 (MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC 10556 (MIC 1.6 uM), and S. mutans
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

L. acidophilus ATCC 4356

Source & Reference

dbAMP

Other

(MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC 10556 (MIC 1.6 uM), and S. mutans UA159 (MIC 12.5 uM) Gram- E. coli ATC
Evidence 6 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

S. sanguis ATCC 10556

Source & Reference

dbAMP

Other

5703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC 10556 (MIC 1.6 uM), and S. mutans UA159 (MIC 12.5 uM) Gram- E. coli ATCC 25922, IS or D31 (13.3-53.2 uM) V
Evidence 7 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

S. mutans UA159

Source & Reference

dbAMP

Other

IC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC 10556 (MIC 1.6 uM), and S. mutans UA159 (MIC 12.5 uM) Gram- E. coli ATCC 25922, IS or D31 (13.3-53.2 uM) V. alginolyticus IS (MIC 26.6 uM P.
Evidence 8 Activity

Activity

MIC
Antibacterial
106.8 µM

Target

P.aeruginosa ATCC 15442

Source & Reference

dbAMP

Other

M) Gram- E. coli ATCC 25922, IS or D31 (13.3-53.2 uM) V. alginolyticus IS (MIC 26.6 uM P.aeruginosa ATCC 15442 (MIC 106.8 uM) and C. albicans ATCC 10231 (MIC 26.6 uM). Antibiofilm:bacteria: the peptide also inhibit
Evidence 9 Activity

Activity

MIC
Antibacterial
26.6 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP

Other

3-53.2 uM) V. alginolyticus IS (MIC 26.6 uM P.aeruginosa ATCC 15442 (MIC 106.8 uM) and C. albicans ATCC 10231 (MIC 26.6 uM). Antibiofilm:bacteria: the peptide also inhibited bacterial biofilm formation:S. aureus (
Evidence 10 Activity

Activity

MIC
Antifungal
106.8 µM

Target

B.subtilis ATCC 6633

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus ATCC 43300, MRSA or ATCC 25923 (MIC 6.8-26.6 uM) B.subtilis ATCC 6633 (MIC 106.8 uM), P. gingivalis ATCC 33277 (MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve
Evidence 11 Activity

Activity

MIC
Antifungal
12.5 µM

Target

P. gingivalis ATCC 33277

Source & Reference

dbAMP CAFPdb Antifungipept

Other

us ATCC 43300, MRSA or ATCC 25923 (MIC 6.8-26.6 uM) B.subtilis ATCC 6633 (MIC 106.8 uM), P. gingivalis ATCC 33277 (MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus
Evidence 12 Activity

Activity

MIC
Antifungal
50 µM

Target

B. adolescentis ATCC 15703

Source & Reference

dbAMP CAFPdb Antifungipept

Other

.8-26.6 uM) B.subtilis ATCC 6633 (MIC 106.8 uM), P. gingivalis ATCC 33277 (MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC
Evidence 13 Activity

Activity

MIC
Antifungal
100 µM

Target

B. breve ATCC 15700

Source & Reference

dbAMP CAFPdb Antifungipept

Other

06.8 uM), P. gingivalis ATCC 33277 (MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC 10556 (MIC 1.6 uM), and S. mutans
Evidence 14 Activity

Activity

MIC
Antifungal
25 µM

Target

L. acidophilus ATCC 4356

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 12.5 uM), B. adolescentis ATCC 15703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC 10556 (MIC 1.6 uM), and S. mutans UA159 (MIC 12.5 uM) Gram- E. coli ATC
Evidence 15 Activity

Activity

MIC
Antifungal
1.6 µM

Target

S. sanguis ATCC 10556

Source & Reference

dbAMP CAFPdb Antifungipept

Other

5703 (MIC 50 uM), B. breve ATCC 15700 (MIC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC 10556 (MIC 1.6 uM), and S. mutans UA159 (MIC 12.5 uM) Gram- E. coli ATCC 25922, IS or D31 (13.3-53.2 uM) V
Evidence 16 Activity

Activity

MIC
Antifungal
12.5 µM

Target

S. mutans UA159

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 100 uM), L. acidophilus ATCC 4356 (MIC 25 uM), S. sanguis ATCC 10556 (MIC 1.6 uM), and S. mutans UA159 (MIC 12.5 uM) Gram- E. coli ATCC 25922, IS or D31 (13.3-53.2 uM) V. alginolyticus IS (MIC 26.6 uM P.
Evidence 17 Activity

Activity

MIC
Antifungal
106.8 µM

Target

P.aeruginosa ATCC 15442

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M) Gram- E. coli ATCC 25922, IS or D31 (13.3-53.2 uM) V. alginolyticus IS (MIC 26.6 uM P.aeruginosa ATCC 15442 (MIC 106.8 uM) and C. albicans ATCC 10231 (MIC 26.6 uM). Antibiofilm:bacteria: the peptide also inhibit
Evidence 18 Activity

Activity

MIC
Antifungal
26.6 µM

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

3-53.2 uM) V. alginolyticus IS (MIC 26.6 uM P.aeruginosa ATCC 15442 (MIC 106.8 uM) and C. albicans ATCC 10231 (MIC 26.6 uM). Antibiofilm:bacteria: the peptide also inhibited bacterial biofilm formation:S. aureus (
Evidence 19 Activity

Activity

10% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
10% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The Analogs of Temporin-GHa Exhibit a Broader Spectrum of Antimicrobial Activity and a Stronger Antibiofilm Potential Against Staphylococcus aureus. | Molecules | 2019
Evidence 20 Activity

Activity

50% Hemolysis
Toxicity
115 µM
Hemolytic Cytotoxic
50% Hemolysis | 115 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The Analogs of Temporin-GHa Exhibit a Broader Spectrum of Antimicrobial Activity and a Stronger Antibiofilm Potential Against Staphylococcus aureus. | Molecules | 2019
Evidence 21 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.