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Peptide record

TPDB07162

Antibacterial Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07162
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
DEMKLDGFNMHLE
Physicochemical Analysis
C67H103N17O23S2
ARCQIPSTWYV
DELM
1578.78
4.06
2
4
5
-3
6.17
-0.831
60.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
1
N
2
D
0
C
2
E
0
Q
1
G
1
H
0
I
2
L
1
K
2
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 2 C: 0 E: 2 Q: 0 G: 1 H: 1 I: 0 L: 2 K: 1 M: 2 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C67H103N17O23S2
1578.78
4.06
-3
6.17
-0.831
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
20 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 (MIC 20 uM) and S. aureus ATCC 25923 (MIC 40.5 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
40.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 (MIC 20 uM) and S. aureus ATCC 25923 (MIC 40.5 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
20 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 (MIC 20 uM) and S. aureus ATCC 25923 (MIC 40.5 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
40.5 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 20 uM) and S. aureus ATCC 25923 (MIC 40.5 uM).
Evidence 5 Activity

Activity

0% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
0% Hemolysis | 160 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides. | Molecules | 2018
Evidence 6 Activity

Activity

12% Hemolysis
Toxicity
320 µM
Hemolytic Cytotoxic
12% Hemolysis | 320 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides. | Molecules | 2018
Evidence 7 Activity

Activity

MHC
Toxicity
640 µM
Hemolytic
Hemolytic_activity: [Ref.30423858] 100% hemolysis MHC=640µM against human blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2018 Nov 23(11): 2943. Published online 2018 Nov 11. doi: 10.3390/molecules23112943