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Peptide record

TPDB07118

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07118
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
IKKIWSKIKKLWK
Physicochemical Analysis
C85H143N21O15
ARNDCEQGHMFPTYV
K
1699.20
11.21
6
0
6
+6
0.88
-0.669
120.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
11000
647.36
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
1
L
6
K
0
M
0
F
0
P
1
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 1 K: 6 M: 0 F: 0 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
13
C85H143N21O15
1699.20
11.21
+6
0.88
-0.669
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.50 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 2.50 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermid
Evidence 2 Activity

Activity

MIC
Antibacterial
2.50 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 2.50 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 5.00 uM), Gram- E.
Evidence 3 Activity

Activity

MIC
Antibacterial
10.0 µM

Target

E. faecium

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 2.50 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 5.00 uM), Gram- E. coli (MIC 3.13 uM), P. aer
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µM

Target

B. cereus

Source & Reference

NA

Other

ainst Gram+ S. aureus (MIC 2.50 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 5.00 uM), Gram- E. coli (MIC 3.13 uM), P. aeruginosa (MIC 5.00 uM),
Evidence 5 Activity

Activity

MIC
Antibacterial
5.00 µM

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

MIC 2.50 uM), E. faecalis (MIC 2.50 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 5.00 uM), Gram- E. coli (MIC 3.13 uM), P. aeruginosa (MIC 5.00 uM), K.pneumoniae (MIC >100 uM), E.
Evidence 6 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Escherichia coli

Source & Reference

NA

Other

uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 5.00 uM), Gram- E. coli (MIC 3.13 uM), P. aeruginosa (MIC 5.00 uM), K.pneumoniae (MIC >100 uM), E.cloacae (MIC >100 uM), and P.
Evidence 7 Activity

Activity

MIC
Antibacterial
5.00 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 5.00 uM), Gram- E. coli (MIC 3.13 uM), P. aeruginosa (MIC 5.00 uM), K.pneumoniae (MIC >100 uM), E.cloacae (MIC >100 uM), and P.mirabilis (MIC >100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumoniae

Source & Reference

NA

Other

, S. epidermidis (MIC 5.00 uM), Gram- E. coli (MIC 3.13 uM), P. aeruginosa (MIC 5.00 uM), K.pneumoniae (MIC >100 uM), E.cloacae (MIC >100 uM), and P.mirabilis (MIC >100 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.cloacae

Source & Reference

NA

Other

M), Gram- E. coli (MIC 3.13 uM), P. aeruginosa (MIC 5.00 uM), K.pneumoniae (MIC >100 uM), E.cloacae (MIC >100 uM), and P.mirabilis (MIC >100 uM).
Evidence 10 Activity

Activity

MIC
Antibacterial
>100 µM

Target

P.mirabilis

Source & Reference

NA

Other

M), P. aeruginosa (MIC 5.00 uM), K.pneumoniae (MIC >100 uM), E.cloacae (MIC >100 uM), and P.mirabilis (MIC >100 uM).
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigation of the role of tryptophan residues in cationic antimicrobial peptides to determine the mechanism of antimicrobial action. | J Appl Microbiol | 2013