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Peptide record

TPDB07114

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07114
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
IKKILSKIKKLWK
Physicochemical Analysis
C80H144N20O15
ARNDCEQGHMFPTYV
K
1626.15
11.21
6
0
6
+6
2.17
-0.308
150.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
338.22
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
2
L
6
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 6 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C80H144N20O15
1626.15
11.21
+6
2.17
-0.308
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 12.5 uM), E. faecalis (MIC 5.00 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermid
Evidence 2 Activity

Activity

MIC
Antibacterial
5.00 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 12.5 uM), E. faecalis (MIC 5.00 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 12.5 uM), Gram- E.
Evidence 3 Activity

Activity

MIC
Antibacterial
10.0 µM

Target

E. faecium

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 12.5 uM), E. faecalis (MIC 5.00 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 12.5 uM), Gram- E. coli (MIC 9.37 uM), P. aer
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µM

Target

B. cereus

Source & Reference

NA

Other

ainst Gram+ S. aureus (MIC 12.5 uM), E. faecalis (MIC 5.00 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 12.5 uM), Gram- E. coli (MIC 9.37 uM), P. aeruginosa MRPA0108 persis
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

MIC 12.5 uM), E. faecalis (MIC 5.00 uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 12.5 uM), Gram- E. coli (MIC 9.37 uM), P. aeruginosa MRPA0108 persisters (MIC 18.75-25 uM), K.pneu
Evidence 6 Activity

Activity

MIC
Antibacterial
9.37 µM

Target

Escherichia coli

Source & Reference

NA

Other

uM), E. faecium (MIC 10.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 12.5 uM), Gram- E. coli (MIC 9.37 uM), P. aeruginosa MRPA0108 persisters (MIC 18.75-25 uM), K.pneumoniae (MIC >100 uM), E.cloac
Evidence 7 Activity

Activity

MIC
Antibacterial
18.75-25 µM

Target

Pseudomonas aeruginosa MRPA0108 persisters

Source & Reference

NA

Other

.0 uM), B. cereus (MIC 25 uM), S. epidermidis (MIC 12.5 uM), Gram- E. coli (MIC 9.37 uM), P. aeruginosa MRPA0108 persisters (MIC 18.75-25 uM), K.pneumoniae (MIC >100 uM), E.cloacae (MIC >100 uM), and P.mirabilis (MIC >100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumoniae

Source & Reference

NA

Other

.5 uM), Gram- E. coli (MIC 9.37 uM), P. aeruginosa MRPA0108 persisters (MIC 18.75-25 uM), K.pneumoniae (MIC >100 uM), E.cloacae (MIC >100 uM), and P.mirabilis (MIC >100 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.cloacae

Source & Reference

NA

Other

.37 uM), P. aeruginosa MRPA0108 persisters (MIC 18.75-25 uM), K.pneumoniae (MIC >100 uM), E.cloacae (MIC >100 uM), and P.mirabilis (MIC >100 uM).
Evidence 10 Activity

Activity

MIC
Antibacterial
>100 µM

Target

P.mirabilis

Source & Reference

NA

Other

08 persisters (MIC 18.75-25 uM), K.pneumoniae (MIC >100 uM), E.cloacae (MIC >100 uM), and P.mirabilis (MIC >100 uM).
Evidence 11 Activity

Activity

<1% Hemolysis
Toxicity
3.125 µM
Hemolytic Cytotoxic
<1% Hemolysis | 3.125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synergistic Antibacterial Activity of Designed Trp-Containing Antibacterial Peptides in Combination With Antibiotics Against Multidrug-Resistant Staphylococcus epidermidis. | Front Microbiol | 2019
Evidence 12 Activity

Activity

17% Killing
Toxicity
3.125 µM
Cytotoxic
17% Killing | 3.125 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Synergistic Antibacterial Activity of Designed Trp-Containing Antibacterial Peptides in Combination With Antibiotics Against Multidrug-Resistant Staphylococcus epidermidis. | Front Microbiol | 2019
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigation of the role of tryptophan residues in cationic antimicrobial peptides to determine the mechanism of antimicrobial action. | J Appl Microbiol | 2013