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Peptide record

TPDB07097

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07097
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
FPVTWKWWKWWKG
Physicochemical Analysis
C98H123N21O15
ARNDCEQHILMSY
W
1835.19
10.84
3
0
7
+3
-6.74
-0.915
22.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
27500
1498.49
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
3
K
0
M
1
F
1
P
0
S
1
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 1 P: 1 S: 0 T: 1 W: 5 Y: 0 V: 1
Chemical Descriptors
13
C98H123N21O15
1835.19
10.84
+3
-6.74
-0.915
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mechanism of action of puroindoline derived tryptophan-rich antimicrobial peptides. | Biochim Biophys Acta | 2013
Evidence 2 Activity

Activity

IC50
Toxicity
34.3 µM
Cytotoxic
IC50 | 34.3 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
65 µM
Hemolytic Cytotoxic
Hemolytic_activity: RBC: IC50 ≥ 65 µM | Cytotoxicity: PBMC: IC50=23.0 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.