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Peptide record

TPDB07094

Antibacterial Anticancer Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07094
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPIVGLLKSLLK
Physicochemical Analysis
C72H125N15O15
ARNDCEQHMTWY
L
1440.88
10.60
2
0
8
+2
-1.60
1.531
202.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
5
L
2
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 5 K: 2 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C72H125N15O15
1440.88
10.60
+2
-1.60
1.531
Evidence Records 3 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
48 µM
Hemolytic Cytotoxic
<10% Hemolysis | 48 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide. | Front Chem | 2017
Evidence 2 Activity

Activity

IC50
Toxicity
52 µM
Cytotoxic
IC50 | 52 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide. | Front Chem | 2017
Evidence 3 Activity

Activity

IC50
Toxicity
52 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28443279] 8% hemolysis at 48µM, 38% hemolysis at 96µM against human red cells | Cytotoxicity: [Ref.28443279] IC50 = 52 µM against PBMCs. ##IC50 = 59 µM against A549 cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Chem. 2017 Apr 11 5:24