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Peptide record

TPDB07091

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB07091
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 DRAVP 2.0 PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLKGIVGMLGKLF
Physicochemical Analysis
C70H115N15O14S1
ARNDCEQHPSTWY
GL
1422.84
10.60
2
0
8
+2
-2.40
1.431
142.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
3
L
2
K
1
M
2
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 2 M: 1 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C70H115N15O14S1
1422.84
10.60
+2
-2.40
1.431
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
26 µM
Hemolytic Cytotoxic
50% Hemolysis | 26 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Analogues of temporin-SHa and uses thereof | Patent EP 2853538 A1 | 2015
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Analogues of temporin-SHa and uses thereof | Patent EP 2853538 A1 | 2015
Evidence 3 Activity

Activity

26% Cytotoxicity
Toxicity
10 µM
Cytotoxic
26% Cytotoxicity | 10 | µM | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1. | Viruses | 2019
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.30669255]Significant cytotoxicity was observed on Keratinocyte at the concentration of 10 µM with a cell viability of 74%.

Source & Reference

NA
DRAMP
Viruses. 2019 Jan 18 11(1):77.
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis